Understanding the genetic basis of cancer risk is an international effort. The advent of next-generation sequencing (NGS) in late 2000 has further accelerated the discovery of many cancer susceptibility genes. The use of targeted NGS-panel multigene testing to provide a comprehensive analysis of cancer susceptibility genes has proven to be a viable option, with accurate and robust detection of clinically relevant variants in targeted gene into crucial.
We has been developed and validated tests are targeted based NGS for risk assessment of hereditary cancer using Illumina NGS Platform by analyzing the protein-coding regions of 35 genes hereditary cancer with bioinformatics pipeline that utilize standard practice in the field.
35-offspring cancer panel is designed to identify the gene germline mutations cause cancer to 8 different cancers: breast, ovary, prostate, uterus, colon, pancreatic, gastric cancer and melanoma. Panel validated using DNA specimens were characterized [NIGMS Human Genetic Cell Repository], where the DNA was extracted using the blood of individual genetic variants had previously been characterized by the Genome Project in 1000 and Coriell Catalog.
The 35-gene panel hereditary cancer showed high sensitivity (99.9%) and specificity (100%) in 4820 variants including single nucleotide variants (SNVs) and small insertions and deletions (INDEL; up to 25 bp). Reproducibility and repeatability is 99.8 and 100%, respectively.The use of NGS targeted based multigene test panel to provide a comprehensive analysis of cancer susceptibility genes has been considered as a viable option.
In this study, we developed and validated a 35-gene panel for testing eight common cancers using next-generation sequencing (NGS). Our descent cancer panel performance rated on the board of numerous variants in 35 genes to support the clinical use.
Development and validation of next generation sequencing based 35-gene hereditary cancer panel.
TUBA8
MBS8565103-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
TUBA8
MBS8565103-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
TUBA8
MBS8565103-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
TUBA8 Antibody
48461
SAB
100ul
EUR 429
TUBA8 Antibody
48461-100ul
SAB
100ul
EUR 399.6
TUBA8 Antibody
48461-50ul
SAB
50ul
EUR 286.8
TUBA8 antibody
70R-21058
Fitzgerald
50 ul
EUR 289
Description: Rabbit polyclonal TUBA8 antibody
Tuba8 antibody
70R-9491
Fitzgerald
50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Tuba8 antibody
TUBA8 antibody
70R-9492
Fitzgerald
50 ug
EUR 467
Description: Affinity purified rabbit polyclonal TUBA8 antibody
TUBA8 antibody
10R-6169
Fitzgerald
100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody
TUBA8 antibody
10R-6170
Fitzgerald
100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody
TUBA8 antibody
10R-6171
Fitzgerald
100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody
TUBA8 antibody
10R-6172
Fitzgerald
100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody
TUBA8 Antibody
BF0558-200ul
Affinity Biosciences
200ul
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Description: WB,IHC,IF/ICC,ELISA,FCM
TUBA8 Antibody
1-CSB-PA025314GA01HU
Cusabio
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Description: A polyclonal antibody against TUBA8. Recognizes TUBA8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA
TUBA8 antibody
MBS5301608-005mL
MyBiosource
0.05mL
EUR 495
TUBA8 antibody
MBS5301608-5x05mL
MyBiosource
5x0.5mL
EUR 2075
Tuba8 antibody
MBS5303060-01mL
MyBiosource
0.1mL
EUR 750
Tuba8 antibody
MBS5303060-5x01mL
MyBiosource
5x0.1mL
EUR 3215
TUBA8 antibody
MBS832929-01mL
MyBiosource
0.1mL
EUR 1095
TUBA8 antibody
MBS832929-5x01mL
MyBiosource
5x0.1mL
EUR 4770
TUBA8 antibody
MBS833064-01mL
MyBiosource
0.1mL
EUR 1095
TUBA8 antibody
MBS833064-5x01mL
MyBiosource
5x0.1mL
EUR 4770
TUBA8 Antibody
MBS9435314-005mL
MyBiosource
0.05mL
EUR 325
TUBA8 Antibody
MBS9435314-01mL
MyBiosource
0.1mL
EUR 445
TUBA8 Antibody
MBS9435314-5x01mL
MyBiosource
5x0.1mL
EUR 1860
TUBA8 antibody
MBS834206-01mL
MyBiosource
0.1mL
EUR 1095
TUBA8 antibody
MBS834206-5x01mL
MyBiosource
5x0.1mL
EUR 4770
TUBA8 antibody
MBS834893-01mL
MyBiosource
0.1mL
EUR 1095
TUBA8 antibody
MBS834893-5x01mL
MyBiosource
5x0.1mL
EUR 4770
TUBA8 antibody
MBS839277-01mL
MyBiosource
0.1mL
EUR 750
TUBA8 antibody
MBS839277-5x01mL
MyBiosource
5x0.1mL
EUR 3215
Rat TUBA8 siRNA
20-abx938554
Abbexa
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TUBA8 Mouse mAb
E2222942
EnoGene
100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
TUBA8 Mouse mAb
E2220644
EnoGene
100ul
EUR 225
Description: Available in various conjugation types.
TUBA8 siRNA (Rat)
MBS8225097-15nmol
MyBiosource
15nmol
EUR 405
TUBA8 siRNA (Rat)
MBS8225097-30nmol
MyBiosource
30nmol
EUR 565
TUBA8 siRNA (Rat)
MBS8225097-5x30nmol
MyBiosource
5x30nmol
EUR 2450
TUBA8 Mouse mAb
MBS8538851-01mL
MyBiosource
0.1mL
EUR 305
TUBA8 Mouse mAb
MBS8538851-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
TUBA8 Mouse mAb
MBS8538851-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
TUBA8 Mouse mAb
MBS8538851-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
TUBA8 Mouse mAb
MBS8538851-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Human TUBA8 siRNA
20-abx905867
Abbexa
Ask for price
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Mouse TUBA8 siRNA
20-abx938555
Abbexa
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TUBA8 siRNA (Mouse)
MBS8231794-15nmol
MyBiosource
15nmol
EUR 405
TUBA8 siRNA (Mouse)
MBS8231794-30nmol
MyBiosource
30nmol
EUR 565
TUBA8 siRNA (Mouse)
MBS8231794-5x30nmol
MyBiosource
5x30nmol
EUR 2450
TUBA8 siRNA (Human)
MBS8228315-15nmol
MyBiosource
15nmol
EUR 405
TUBA8 siRNA (Human)
MBS8228315-30nmol
MyBiosource
30nmol
EUR 565
TUBA8 siRNA (Human)
MBS8228315-5x30nmol
MyBiosource
5x30nmol
EUR 2450
Tuba8 Blocking Peptide
33R-1093
Fitzgerald
100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CNTFR antibody, catalog no. 70R-9962
TUBA8 Blocking Peptide
33R-2653
Fitzgerald
100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TUBA8 antibody, catalog no. 70R-9492
TUBA8 Blocking Peptide
BF0558-BP
Affbiotech
1mg
EUR 234
TUBA8 Blocking Peptide
MBS9620175-1mg
MyBiosource
1mg
EUR 380
TUBA8 Blocking Peptide
MBS9620175-5x1mg
MyBiosource
5x1mg
EUR 1650
TUBA8 Conjugated Antibody
C48461
SAB
100ul
EUR 476.4
TUBA8 Conjugated Antibody
MBS9456427-01mLAF350
MyBiosource
0.1mL(AF350)
EUR 480
TUBA8 Conjugated Antibody
MBS9456427-01mLAF405
MyBiosource
0.1mL(AF405)
EUR 480
TUBA8 Conjugated Antibody
MBS9456427-01mLAF488
MyBiosource
0.1mL(AF488)
EUR 480
TUBA8 Conjugated Antibody
MBS9456427-01mLAF555
MyBiosource
0.1mL(AF555)
EUR 480
TUBA8 Conjugated Antibody
MBS9456427-01mLBiotin
MyBiosource
0.1mL(Biotin)
EUR 480
TUBA8 (GFP-tagged) - Human tubulin, alpha 8 (TUBA8), transcript variant 1
RG211175
Origene Technologies GmbH
10 µg
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TUBA8 (GFP-tagged) - Human tubulin, alpha 8 (TUBA8), transcript variant 2
RG230818
Origene Technologies GmbH
10 µg
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Rat TUBA8 shRNA Plasmid
20-abx990973
Abbexa
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Lenti ORF clone of Tuba8 (mGFP-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MR207173L4
Origene Technologies GmbH
10 µg
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Mouse TUBA8 shRNA Plasmid
20-abx974377
Abbexa
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Human TUBA8 shRNA Plasmid
20-abx959952
Abbexa
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Anti-TBA8 TUBA8 Antibody
A08793
BosterBio
100ul
EUR 380
Description: Boster Bio Anti-TBA8 TUBA8 Antibody catalog # A08793. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Human TUBA8 Protein Lysate
MBS8429323-INQUIRE
MyBiosource
INQUIRE
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TUBA8 (NM_018943) Human Recombinant Protein
E45H36939M5
EnoGene
20 ug
EUR 785.42
Tuba8 (NM_017379) Mouse Recombinant Protein
E45M46309M5
EnoGene
20 ug
EUR 1924.54
TUBA8 (NM_018943) Human Recombinant Protein
PROTQ9NY65
BosterBio
20ug
EUR 1249
Description: Recombinant protein of human tubulin, alpha 8 (TUBA8)
TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818
Origene Technologies GmbH
10 µg
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TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 1
RC211175
Origene Technologies GmbH
10 µg
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TUBA8 Recombinant Protein (Rat)
RP235268
ABM
100 ug
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TUBA8 Recombinant Protein (Human)
RP105950
ABM
100 ug
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TUBA8 Recombinant Protein (Mouse)
RP182228
ABM
100 ug
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TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-100g
Abbexa
100 µg
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TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
20-abx329824
Abbexa
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TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-20g
Abbexa
20 µg
EUR 187.5
TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-50g
Abbexa
50 µg
EUR 250
TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
1-CSB-PA193238
Cusabio
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Description: A polyclonal antibody against TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A. Recognizes TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000
TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-005mg
MyBiosource
0.05mg
EUR 150
TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-01mg
MyBiosource
0.1mg
EUR 190
TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-5x01mg
MyBiosource
5x0.1mg
EUR 845
Lenti ORF clone of Tuba8 (Myc-DDK-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MR207173L3
Origene Technologies GmbH
10 µg
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Tuba8 ORF Vector (Rat) (pORF)
ORF078424
ABM
1.0 ug DNA
EUR 607.2
TUBA8 ORF Vector (Human) (pORF)
ORF035318
ABM
1.0 ug DNA
EUR 486
Tuba8 ORF Vector (Mouse) (pORF)
ORF060744
ABM
1.0 ug DNA
EUR 607.2
Tubulin, Alpha 8 (TUBA8) Antibody
20-abx116348
Abbexa
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Tubulin, Alpha 8 (TUBA8) Antibody
abx116348-50g
Abbexa
50 µg
EUR 612.5
Human TUBA8 knockout cell line
ABC-KH16329
AcceGen
1 vial
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Description: Human TUBA8 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.
Human, Rat, Mouse TUBA8 antibody
P1002
Omnimabs
100ul
EUR 150
TUBA8 (NM_018943) Human Over-expression Lysate
E45H10881-2
EnoGene
each
EUR 395
TUBA8 (NM_018943) Human Over-expression Lysate
LS051807
BosterBio
100ug
EUR 628
Description: Transient overexpression lysate of tubulin, alpha 8 (TUBA8)
Human TUBA8 knockdown cell line
ABC-KD16329
AcceGen
1 vial
Ask for price
Description: Human TUBA8 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.
Human TUBA8 Protein Lysate 20ug
IHUTUBA8PLLY20UG
Innovative research
each
EUR 213
Description: Human TUBA8 Protein Lysate 20ug
Lenti ORF clone of Tuba8 (mGFP-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RR205066L4
Origene Technologies GmbH
10 µg
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Tuba8 Peptide - N-terminal region
MBS3238227-01mg
MyBiosource
0.1mg
EUR 180
Tuba8 Peptide - N-terminal region
MBS3238227-5x01mg
MyBiosource
5x0.1mg
EUR 730
TUBA8 Peptide - N-terminal region
MBS3238228-01mg
MyBiosource
0.1mg
EUR 180
TUBA8 Peptide - N-terminal region
MBS3238228-5x01mg
MyBiosource
5x0.1mg
EUR 730
Mouse Monoclonal Antibody to TUBA8
E10-30301
EnoGene
100ul
EUR 225
Description: Available in various conjugation types.
Tuba8 antibody - N-terminal region
MBS3213282-01mL
MyBiosource
0.1mL
EUR 455
Tuba8 antibody - N-terminal region
MBS3213282-5x01mL
MyBiosource
5x0.1mL
EUR 1995
TUBA8 antibody - N-terminal region
MBS3213283-01mL
MyBiosource
0.1mL
EUR 455
TUBA8 antibody - N-terminal region
MBS3213283-5x01mL
MyBiosource
5x0.1mL
EUR 1995
Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mL
MyBiosource
0.1mL
EUR 305
Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Mouse Monoclonal Antibody to TUBA8
MBS8528472-01mL
MyBiosource
0.1mL
EUR 320
Monoclonal TUBA8 Antibody, Clone: 2D6
APR13863G
Leading Biology
0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human TUBA8. The antibodies are raised in Mouse and are from clone 2D6. This antibody is applicable in WB and IHC, FC, ICC, E
Lenti ORF particles, Tuba8 (GFP-tagged) - Mouse tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
MR207173L4V
Origene Technologies GmbH
200 µl
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TUBA8 Over-expression Lysate Product
GWB-7C0DE4
GenWay Biotech
0.1 mg
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Lenti ORF clone of Tuba8 (Myc-DDK-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RR205066L3
Origene Technologies GmbH
10 µg
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Lenti-ORF clone of TUBA8 (mGFP-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818L4
Origene Technologies GmbH
10 µg
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Lenti ORF particles, Tuba8 (GFP-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
RR205066L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, Tuba8 (Myc-DDK-tagged) - Mouse tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
MR207173L3V
Origene Technologies GmbH
200 µl
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Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-100g
Abbexa
100 µg
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Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-100ul
Abbexa
100 ul
EUR 493.2
Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-10g
Abbexa
10 µg
EUR 362.5
Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-200g
Abbexa
200 µg
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Tubulin Alpha-8 Chain (TUBA8) Antibody
abx376467-96tests
Abbexa
96 tests
EUR 225
Lenti-ORF clone of TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818L3
Origene Technologies GmbH
10 µg
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Lenti ORF particles, Tuba8 (Myc-DDK-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
RR205066L3V
Origene Technologies GmbH
200 µl
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Tuba8 sgRNA CRISPR Lentivector set (Rat)
K6710901
ABM
3 x 1.0 ug
EUR 406.8
Tubulin alpha 8 (TUBA8) polyclonal antibody
ABP-PAB-01423
Allele Biotech
100 ug
Ask for price
TUBA8 sgRNA CRISPR Lentivector set (Human)
K2557901
ABM
3 x 1.0 ug
EUR 406.8
Tuba8 sgRNA CRISPR Lentivector set (Mouse)
K3429401
ABM
3 x 1.0 ug
EUR 406.8