Understanding the genetic basis of cancer risk is an international effort. The advent of next-generation sequencing (NGS) in late 2000 has further accelerated the discovery of many cancer susceptibility genes. The use of targeted NGS-panel multigene testing to provide a comprehensive analysis of cancer susceptibility genes has proven to be a viable option, with accurate and robust detection of clinically relevant variants in targeted gene into crucial.We has been developed and validated tests are targeted based NGS for risk assessment of hereditary cancer using Illumina NGS Platform by analyzing the protein-coding regions of 35 genes hereditary cancer with bioinformatics pipeline that utilize standard practice in the field. 35-offspring cancer panel is designed to identify the gene germline mutations cause cancer to 8 different cancers: breast, ovary, prostate, uterus, colon, pancreatic, gastric cancer and melanoma. Panel validated using DNA specimens were characterized [NIGMS Human Genetic Cell Repository], where the DNA was extracted using the blood of individual genetic variants had previously been characterized by the Genome Project in 1000 and Coriell Catalog.The 35-gene panel hereditary cancer showed high sensitivity (99.9%) and specificity (100%) in 4820 variants including single nucleotide variants (SNVs) and small insertions and deletions (INDEL; up to 25 bp). Reproducibility and repeatability is 99.8 and 100%, respectively.The use of NGS targeted based multigene test panel to provide a comprehensive analysis of cancer susceptibility genes has been considered as a viable option. In this study, we developed and validated a 35-gene panel for testing eight common cancers using next-generation sequencing (NGS). Our descent cancer panel performance rated on the board of numerous variants in 35 genes to support the clinical use.

Development and validation of next generation sequencing based 35-gene hereditary cancer panel.

by

Understanding the genetic basis of cancer risk is an international effort. The advent of next-generation sequencing (NGS) in late 2000 has further accelerated the discovery of many cancer susceptibility genes. The use of targeted NGS-panel multigene testing to provide a comprehensive analysis of cancer susceptibility genes has proven to be a viable option, with accurate and robust detection of clinically relevant variants in targeted gene into crucial.

We has been developed and validated tests are targeted based NGS for risk assessment of hereditary cancer using Illumina NGS Platform by analyzing the protein-coding regions of 35 genes hereditary cancer with bioinformatics pipeline that utilize standard practice in the field.

35-offspring cancer panel is designed to identify the gene germline mutations cause cancer to 8 different cancers: breast, ovary, prostate, uterus, colon, pancreatic, gastric cancer and melanoma. Panel validated using DNA specimens were characterized [NIGMS Human Genetic Cell Repository], where the DNA was extracted using the blood of individual genetic variants had previously been characterized by the Genome Project in 1000 and Coriell Catalog.

The 35-gene panel hereditary cancer showed high sensitivity (99.9%) and specificity (100%) in 4820 variants including single nucleotide variants (SNVs) and small insertions and deletions (INDEL; up to 25 bp). Reproducibility and repeatability is 99.8 and 100%, respectively.The use of NGS targeted based multigene test panel to provide a comprehensive analysis of cancer susceptibility genes has been considered as a viable option.

In this study, we developed and validated a 35-gene panel for testing eight common cancers using next-generation sequencing (NGS). Our descent cancer panel performance rated on the board of numerous variants in 35 genes to support the clinical use.

Understanding the genetic basis of cancer risk is an international effort. The advent of next-generation sequencing (NGS) in late 2000 has further accelerated the discovery of many cancer susceptibility genes. The use of targeted NGS-panel multigene testing to provide a comprehensive analysis of cancer susceptibility genes has proven to be a viable option, with accurate and robust detection of clinically relevant variants in targeted gene into crucial.We has been developed and validated tests are targeted based NGS for risk assessment of hereditary cancer using Illumina NGS Platform by analyzing the protein-coding regions of 35 genes hereditary cancer with bioinformatics pipeline that utilize standard practice in the field. 35-offspring cancer panel is designed to identify the gene germline mutations cause cancer to 8 different cancers: breast, ovary, prostate, uterus, colon, pancreatic, gastric cancer and melanoma. Panel validated using DNA specimens were characterized [NIGMS Human Genetic Cell Repository], where the DNA was extracted using the blood of individual genetic variants had previously been characterized by the Genome Project in 1000 and Coriell Catalog.The 35-gene panel hereditary cancer showed high sensitivity (99.9%) and specificity (100%) in 4820 variants including single nucleotide variants (SNVs) and small insertions and deletions (INDEL; up to 25 bp). Reproducibility and repeatability is 99.8 and 100%, respectively.The use of NGS targeted based multigene test panel to provide a comprehensive analysis of cancer susceptibility genes has been considered as a viable option. In this study, we developed and validated a 35-gene panel for testing eight common cancers using next-generation sequencing (NGS). Our descent cancer panel performance rated on the board of numerous variants in 35 genes to support the clinical use.
Development and validation of next generation sequencing based 35-gene hereditary cancer panel.

TUBA8
MBS8565103-01mLAF610 0.1mL(AF610)
EUR 565

TUBA8
MBS8565103-01mLAF635 0.1mL(AF635)
EUR 565

TUBA8 siRNA
20-abx905867
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  • 15 nmol
  • 30 nmol

TUBA8 siRNA
20-abx938554
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  • 15 nmol
  • 30 nmol

TUBA8 siRNA
20-abx938555
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  • Ask for price
  • 15 nmol
  • 30 nmol

TUBA8 antibody
10R-6169 100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody

TUBA8 antibody
10R-6170 100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody

TUBA8 antibody
10R-6171 100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody

TUBA8 antibody
10R-6172 100 ul
EUR 709
Description: Mouse monoclonal TUBA8 antibody

TUBA8 Antibody
48461 100ul
EUR 429

TUBA8 Antibody
48461-100ul 100ul
EUR 399.6

TUBA8 Antibody
48461-50ul 50ul
EUR 286.8

TUBA8 Antibody
1-CSB-PA025314GA01HU
  • Ask for price
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  • 150ul
  • 50ul
Description: A polyclonal antibody against TUBA8. Recognizes TUBA8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA

TUBA8 antibody
70R-21058 50 ul
EUR 289
Description: Rabbit polyclonal TUBA8 antibody

Tuba8 antibody
70R-9491 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Tuba8 antibody

TUBA8 antibody
70R-9492 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal TUBA8 antibody

TUBA8 Antibody
GWB-4F5ABD 0.1 ml Ask for price

TUBA8 Antibody
GWB-1C0232 0.1 ml Ask for price

TUBA8 Antibody
GWB-AC0A61 0.1 ml Ask for price

Tuba8 Antibody
GWB-MU766A 50ug Ask for price

TUBA8 Antibody
GWB-MU767B 50ug Ask for price

TUBA8 antibody
BF0558 100ug
EUR 355

TUBA8 antibody
MBS832929-01mL 0.1mL
EUR 1095

TUBA8 antibody
MBS832929-5x01mL 5x0.1mL
EUR 4770

TUBA8 antibody
MBS833064-01mL 0.1mL
EUR 1095

TUBA8 antibody
MBS833064-5x01mL 5x0.1mL
EUR 4770

TUBA8 antibody
MBS834206-01mL 0.1mL
EUR 1095

TUBA8 antibody
MBS834206-5x01mL 5x0.1mL
EUR 4770

TUBA8 antibody
MBS834893-01mL 0.1mL
EUR 1095

TUBA8 antibody
MBS834893-5x01mL 5x0.1mL
EUR 4770

TUBA8 antibody
MBS839277-01mL 0.1mL
EUR 750

TUBA8 antibody
MBS839277-5x01mL 5x0.1mL
EUR 3215

TUBA8 antibody
MBS5301608-005mL 0.05mL
EUR 495

TUBA8 antibody
MBS5301608-5x05mL 5x0.5mL
EUR 2075

Tuba8 antibody
MBS5303060-01mL 0.1mL
EUR 750

Tuba8 antibody
MBS5303060-5x01mL 5x0.1mL
EUR 3215

TUBA8 Antibody
MBS9435314-005mL 0.05mL
EUR 325

TUBA8 Antibody
MBS9435314-01mL 0.1mL
EUR 445

TUBA8 Antibody
MBS9435314-5x01mL 5x0.1mL
EUR 1860

TUBA8 Antibody
BF0558-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA,FCM

TUBA8 Antibody
BF0558-200ul 200ul Ask for price
Description: WB,IHC,IF/ICC,ELISA,FCM

TUBA8 Antibody
BF0558-50ul 50ul
EUR 150
Description: WB,IHC,IF/ICC,ELISA,FCM

Tuba8 (GFP-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MG207173 10 µg Ask for price

Tuba8 (untagged) - Mouse tubulin, alpha 8 (Tuba8), (10ug)
MC201258 10 µg Ask for price

Tuba8 (Myc-DDK-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MR207173 10 µg Ask for price

TUBA8 Mouse mAb
E2220644 100ul
EUR 225
Description: Available in various conjugation types.

TUBA8 Mouse mAb
E2222942 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TUBA8 siRNA (Rat)
MBS8225097-15nmol 15nmol
EUR 405

TUBA8 siRNA (Rat)
MBS8225097-30nmol 30nmol
EUR 565

TUBA8 siRNA (Rat)
MBS8225097-5x30nmol 5x30nmol
EUR 2450

TUBA8 Mouse mAb
MBS8538851-01mL 0.1mL
EUR 305

TUBA8 Mouse mAb
MBS8538851-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBA8 Mouse mAb
MBS8538851-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBA8 Mouse mAb
MBS8538851-01mLAF610 0.1mL(AF610)
EUR 565

TUBA8 Mouse mAb
MBS8538851-01mLAF635 0.1mL(AF635)
EUR 565

TUBA8 siRNA (Mouse)
MBS8231794-15nmol 15nmol
EUR 405

TUBA8 siRNA (Mouse)
MBS8231794-30nmol 30nmol
EUR 565

TUBA8 siRNA (Mouse)
MBS8231794-5x30nmol 5x30nmol
EUR 2450

TUBA8 siRNA (Human)
MBS8228315-15nmol 15nmol
EUR 405

TUBA8 siRNA (Human)
MBS8228315-30nmol 30nmol
EUR 565

TUBA8 siRNA (Human)
MBS8228315-5x30nmol 5x30nmol
EUR 2450

Tuba8 (untagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RN205066 10 µg Ask for price

Tuba8 Blocking Peptide
33R-1093 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CNTFR antibody, catalog no. 70R-9962

TUBA8 Blocking Peptide
33R-2653 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TUBA8 antibody, catalog no. 70R-9492

TUBA8 Blocking Peptide
BF0558-BP 1mg
EUR 234

TUBA8 Blocking Peptide
MBS9620175-1mg 1mg
EUR 380

TUBA8 Blocking Peptide
MBS9620175-5x1mg 5x1mg
EUR 1650

TUBA8 Conjugated Antibody
C48461 100ul
EUR 476.4

TUBA8 Conjugated Antibody
MBS9456427-01mLAF350 0.1mL(AF350)
EUR 480

TUBA8 Conjugated Antibody
MBS9456427-01mLAF405 0.1mL(AF405)
EUR 480

TUBA8 Conjugated Antibody
MBS9456427-01mLAF488 0.1mL(AF488)
EUR 480

TUBA8 Conjugated Antibody
MBS9456427-01mLAF555 0.1mL(AF555)
EUR 480

TUBA8 Conjugated Antibody
MBS9456427-01mLBiotin 0.1mL(Biotin)
EUR 480

TUBA8 (untagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 1
SC113339 10 µg Ask for price

TUBA8 (GFP-tagged) - Human tubulin, alpha 8 (TUBA8), transcript variant 2
RG230818 10 µg Ask for price

TUBA8 (GFP-tagged) - Human tubulin, alpha 8 (TUBA8), transcript variant 1
RG211175 10 µg Ask for price

Rat Tuba8 ELISA Kit
ELI-53134r 96tests
EUR 756

Tuba8 (Myc-DDK-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RR205066 10 µg Ask for price

Rat TUBA8 shRNA Plasmid
20-abx990973
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  • 150 µg
  • 300 µg

Lenti ORF clone of Tuba8 (mGFP-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MR207173L4 10 µg Ask for price

Mouse TUBA8 shRNA Plasmid
20-abx974377
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  • Ask for price
  • 150 µg
  • 300 µg

Human TUBA8 shRNA Plasmid
20-abx959952
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  • Ask for price
  • 150 µg
  • 300 µg

Anti-TBA8 TUBA8 Antibody
A08793 100ul
EUR 380
Description: Boster Bio Anti-TBA8 TUBA8 Antibody catalog # A08793. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Human TUBA8 Protein Lysate
MBS8429323-INQUIRE INQUIRE Ask for price

TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 1
RC211175 10 µg Ask for price

TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818 10 µg Ask for price

TUBA8 (NM_018943) Human Recombinant Protein
PROTQ9NY65 20ug
EUR 1249
Description: Recombinant protein of human tubulin, alpha 8 (TUBA8)

TUBA8 Recombinant Protein (Rat)
RP235268 100 ug Ask for price

TUBA8 Recombinant Protein (Human)
RP105950 100 ug Ask for price

TUBA8 Recombinant Protein (Mouse)
RP182228 100 ug Ask for price

OAGA03582-100UL - TUBA8 Antibody
OAGA03582-100UL 100ul
EUR 369

Lenti ORF clone of Tuba8 (Myc-DDK-tagged) - Mouse tubulin, alpha 8 (Tuba8)
MR207173L3 10 µg Ask for price

TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
20-abx329824
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  • 100 ug
  • 50 ug

TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
1-CSB-PA193238
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  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A. Recognizes TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000

TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-100g 100 µg Ask for price

TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-20g 20 µg
EUR 187.5

TUBA1A / TUBA1B / TUBA1C / TUBA3C / TUBA8 / TUBA4A Antibody
abx329824-50g 50 µg
EUR 250

TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-005mg 0.05mg
EUR 150

TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-01mg 0.1mg
EUR 190

TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA8/TUBA4A Antibody
MBS7123010-5x01mg 5x0.1mg
EUR 845

Tuba8 ORF Vector (Rat) (pORF)
ORF078424 1.0 ug DNA
EUR 607.2

TUBA8 ORF Vector (Human) (pORF)
ORF035318 1.0 ug DNA
EUR 486

Tuba8 ORF Vector (Mouse) (pORF)
ORF060744 1.0 ug DNA
EUR 607.2

Tubulin, Alpha 8 (TUBA8) Antibody
20-abx116348
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Tubulin, Alpha 8 (TUBA8) Antibody
abx116348-50g 50 µg
EUR 612.5

Human TUBA8 knockout cell line
ABC-KH16329 1 vial Ask for price
Description: Human TUBA8 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human, Rat, Mouse TUBA8 antibody
P1002 100ul
EUR 150

TUBA8 (NM_018943) Human Over-expression Lysate
LS051807 100ug
EUR 628
Description: Transient overexpression lysate of tubulin, alpha 8 (TUBA8)

Human TUBA8 knockdown cell line
ABC-KD16329 1 vial Ask for price
Description: Human TUBA8 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human TUBA8 Protein Lysate 20ug
IHUTUBA8PLLY20UG each
EUR 213
Description: Human TUBA8 Protein Lysate 20ug

Lenti ORF clone of Tuba8 (mGFP-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RR205066L4 10 µg Ask for price

Tuba8 Peptide - N-terminal region
MBS3238227-01mg 0.1mg
EUR 180

Tuba8 Peptide - N-terminal region
MBS3238227-5x01mg 5x0.1mg
EUR 730

TUBA8 Peptide - N-terminal region
MBS3238228-01mg 0.1mg
EUR 180

TUBA8 Peptide - N-terminal region
MBS3238228-5x01mg 5x0.1mg
EUR 730

Mouse Monoclonal Antibody to TUBA8
E10-30301 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to TUBA8
sAP-0651 50ug
EUR 270

Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mL 0.1mL
EUR 305

Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF405L 0.1mL(AF405L)
EUR 565

Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF405S 0.1mL(AF405S)
EUR 565

Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF610 0.1mL(AF610)
EUR 565

Mouse Monoclonal Antibody to TUBA8
MBS8537047-01mLAF635 0.1mL(AF635)
EUR 565

Mouse Monoclonal Antibody to TUBA8
MBS8528472-01mL 0.1mL
EUR 320

Tuba8 antibody - N-terminal region
MBS3213282-01mL 0.1mL
EUR 455

Tuba8 antibody - N-terminal region
MBS3213282-5x01mL 5x0.1mL
EUR 1995

TUBA8 antibody - N-terminal region
MBS3213283-01mL 0.1mL
EUR 455

TUBA8 antibody - N-terminal region
MBS3213283-5x01mL 5x0.1mL
EUR 1995

Monoclonal TUBA8 Antibody, Clone: 2D6
APR13863G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human TUBA8. The antibodies are raised in Mouse and are from clone 2D6. This antibody is applicable in WB and IHC, FC, ICC, E

Lenti ORF particles, Tuba8 (GFP-tagged) - Mouse tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
MR207173L4V 200 µl Ask for price

OCOA09426-20UG - TUBA8 Protein Lysate
OCOA09426-20UG 20ug
EUR 169

TUBA8 Over-expression Lysate Product
GWB-7C0DE4 0.1 mg Ask for price

OAOA21911-100UG - TUBA8 Capture Antibody
OAOA21911-100UG 100ug
EUR 419

OAOA21912-100UG - TUBA8 Capture Antibody
OAOA21912-100UG 100ug
EUR 419

Lenti-ORF clone of TUBA8 (mGFP-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818L4 10 µg Ask for price

Lenti ORF clone of Tuba8 (Myc-DDK-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), (10 ug)
RR205066L3 10 µg Ask for price

OAOA22332-50UG - TUBA8 Detection Antibody
OAOA22332-50UG 50ug
EUR 439

OAOA22333-50UG - TUBA8 Detection Antibody
OAOA22333-50UG 50ug
EUR 439

OAOA22341-50UG - TUBA8 Detection Antibody
OAOA22341-50UG 50ug
EUR 439

OAOA22342-50UG - TUBA8 Detection Antibody
OAOA22342-50UG 50ug
EUR 439

Lenti ORF particles, Tuba8 (GFP-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
RR205066L4V 200 µl Ask for price

Lenti ORF particles, Tuba8 (Myc-DDK-tagged) - Mouse tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
MR207173L3V 200 µl Ask for price

Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-100ul 100 ul
EUR 493.2

Tubulin Alpha-8 Chain (TUBA8) Antibody
abx376467-96tests 96 tests
EUR 225

Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-100g 100 µg Ask for price

Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-10g 10 µg
EUR 362.5

Tubulin Alpha-8 Chain (TUBA8) Antibody
abx011988-200g 200 µg Ask for price

Lenti-ORF clone of TUBA8 (Myc-DDK-tagged)-Human tubulin, alpha 8 (TUBA8), transcript variant 2
RC230818L3 10 µg Ask for price

Lenti ORF particles, Tuba8 (Myc-DDK-tagged ORF) - Rat tubulin, alpha 8 (Tuba8), 200ul, >10^7 TU/mL
RR205066L3V 200 µl Ask for price

Tuba8 sgRNA CRISPR Lentivector set (Rat)
K6710901 3 x 1.0 ug
EUR 406.8

Tubulin alpha 8 (TUBA8) polyclonal antibody
ABP-PAB-01423 100 ug Ask for price

Tuba8 sgRNA CRISPR Lentivector set (Mouse)
K3429401 3 x 1.0 ug
EUR 406.8

TUBA8 sgRNA CRISPR Lentivector set (Human)
K2557901 3 x 1.0 ug
EUR 406.8

Tuba8 3'UTR GFP Stable Cell Line
TU171355 1.0 ml Ask for price

Tuba8 3'UTR GFP Stable Cell Line
TU272652 1.0 ml Ask for price

TUBA8 3'UTR GFP Stable Cell Line
TU077512 1.0 ml
EUR 1672.8

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