objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.
method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.
result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.
conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.
 TAME Hydrochloride |
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| 2050-500 | Biovision | EUR 338 | |
 Verapamil hydrochloride |
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| 2861-1G | Biovision | EUR 131 | |
Verapamil hydrochloride |
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| 2861-5G | Biovision | EUR 327 | |
 Ticlopidine hydrochloride |
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| 2919-25 | Biovision | EUR 403 | |
Ticlopidine hydrochloride |
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| 2919-5 | Biovision | EUR 153 | |
 EHNA hydrochloride |
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| 2265-25 | Biovision | EUR 283 | |
EHNA hydrochloride |
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| 2265-5 | Biovision | EUR 115 | |
 AdipoRon hydrochloride |
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| 2572-25 | Biovision | EUR 588 | |
AdipoRon hydrochloride |
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| 2572-5 | Biovision | EUR 185 | |
 Pargyline hydrochloride |
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| 2618-1000 | Biovision | EUR 175 | |
Pargyline hydrochloride |
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| 2618-500 | Biovision | EUR 120 | |
 Clorgyline hydrochloride |
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| 2622-10 | Biovision | EUR 120 | |
Clorgyline hydrochloride |
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| 2622-50 | Biovision | EUR 327 | |
 Clindamycin hydrochloride |
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| 2627-10 | Biovision | EUR 131 | |
Clindamycin hydrochloride |
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| 2627-50 | Biovision | EUR 370 | |
 Loperamide hydrochloride |
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| 2683-1000 | Biovision | EUR 185 | |
Loperamide hydrochloride |
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| 2683-500 | Biovision | EUR 131 | |
 Clonidine hydrochloride |
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| 2684-100 | Biovision | EUR 131 | |
Clonidine hydrochloride |
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| 2684-500 | Biovision | EUR 359 | |
 Leelamine hydrochloride |
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| 2717-25 | Biovision | EUR 457 | |
Leelamine hydrochloride |
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| 2717-5 | Biovision | EUR 153 | |
 SBE13 hydrochloride |
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| 2847-10 | Biovision | EUR 185 | |
SBE13 hydrochloride |
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| 2847-50 | Biovision | EUR 588 | |
 Amodiaquine hydrochloride |
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| A085-5G | TOKU-E | 5 g | EUR 55 |
 Metformin, Hydrochloride |
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| 1691-5G | Biovision | EUR 158 | |
 Irinotecan Hydrochloride |
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| 1752-250 | Biovision | EUR 387 | |
Irinotecan Hydrochloride |
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| 1752-50 | Biovision | EUR 147 | |
 Epirubicin Hydrochloride |
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| 1753-25 | Biovision | EUR 457 | |
Epirubicin Hydrochloride |
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| 1753-5 | Biovision | EUR 158 | |
 Gemcitabine Hydrochloride |
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| 1759-100 | Biovision | EUR 370 | |
Gemcitabine Hydrochloride |
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| 1759-25 | Biovision | EUR 156 | |
 Amiodarone Hydrochloride |
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| 1828-100 | Biovision | EUR 126 | |
Amiodarone Hydrochloride |
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| 1828-500 | Biovision | EUR 338 | |
 Phenformin hydrochloride |
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| 1889-100 | Biovision | EUR 115 | |
Phenformin hydrochloride |
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| 1889-1000 | Biovision | EUR 359 | |
 Tomatidine hydrochloride |
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| 1893-25 | Biovision | EUR 137 | |
 Vancomycin Hydrochloride |
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| B1507-1G | Biovision | EUR 153 | |
Vancomycin Hydrochloride |
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| B1507-250 | Biovision | EUR 120 | |
Vancomycin Hydrochloride |
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| B1507-5G | Biovision | EUR 262 | |
 Lincomycin Hydrochloride |
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| B1524-1G | Biovision | EUR 142 | |
Lincomycin Hydrochloride |
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| B1524-5G | Biovision | EUR 403 | |
 Minocycline Hydrochloride |
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| B1525-250 | Biovision | EUR 414 | |
Minocycline Hydrochloride |
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| B1525-50 | Biovision | EUR 142 | |
 Oxytetracycline Hydrochloride |
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| B1527-25G | Biovision | EUR 229 | |
Oxytetracycline Hydrochloride |
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| B1527-5G | Biovision | EUR 109 | |
 Tetracycline Hydrochloride |
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| B1535-10G | Biovision | EUR 109 | |
Tetracycline Hydrochloride |
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| B1535-50G | Biovision | EUR 196 | |
 Hydroxyfasudil Hydrochloride |
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| B1559-25 | Biovision | EUR 631 | |
Hydroxyfasudil Hydrochloride |
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| B1559-5 | Biovision | EUR 196 | |
 Thioridazine Hydrochloride |
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| B1581-1G | Biovision | EUR 120 | |
Thioridazine Hydrochloride |
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| B1581-5G | Biovision | EUR 327 | |
 Ivabradine Hydrochloride |
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| B1595-10 | Biovision | EUR 142 | |
 Bendamustine Hydrochloride |
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| B1596-25 | Biovision | EUR 457 | |
Bendamustine Hydrochloride |
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| B1596-5 | Biovision | EUR 153 | |
 Afuresertib hydrochloride |
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| B1848-5 | Biovision | EUR 175 | |
 Chlorpromazine hydrochloride |
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| B1992-100 | Biovision | EUR 120 | |
Chlorpromazine hydrochloride |
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| B1992-500 | Biovision | EUR 294 | |
 Triflupromazine hydrochloride |
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| B1993-100 | Biovision | EUR 120 | |
 ZLN024 hydrochloride |
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| B2034-25 | Biovision | EUR 588 | |
ZLN024 hydrochloride |
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| B2034-5 | Biovision | EUR 185 | |
 Topotecan hydrochloride |
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| B2050-10 | Biovision | EUR 131 | |
 Givinostat hydrochloride |
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| B2081-25 | Biovision | EUR 756 | |
Givinostat hydrochloride |
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| B2081-5 | Biovision | EUR 229 | |
 Moexipril hydrochloride |
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| B2134-25 | Biovision | EUR 294 | |
 Imidapril hydrochloride |
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| B2135-25 | Biovision | EUR 414 | |
Imidapril hydrochloride |
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| B2135-5 | Biovision | EUR 142 | |
 Benazepril hydrochloride |
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| B2138-250 | Biovision | EUR 294 | |
Benazepril hydrochloride |
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| B2138-50 | Biovision | EUR 131 | |
 Dorzolamide hydrochloride |
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| B2185-10 | Biovision | EUR 120 | |
Dorzolamide hydrochloride |
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| B2185-50 | Biovision | EUR 327 | |
 Eltoprazine hydrochloride |
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| B2301-25 | Biovision | EUR 457 | |
Eltoprazine hydrochloride |
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| B2301-5 | Biovision | EUR 153 | |
 Papaverine hydrochloride |
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| B2315-250 | Biovision | EUR 262 | |
Papaverine hydrochloride |
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| B2315-50 | Biovision | EUR 120 | |
 Sarecycline hydrochloride |
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| B2383-25 | Biovision | EUR 588 | |
Sarecycline hydrochloride |
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| B2383-5 | Biovision | EUR 185 | |
) Sertraline (hydrochloride) |
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| B2393-10 | Biovision | EUR 131 | |
Sertraline (hydrochloride) |
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| B2393-50 | Biovision | EUR 327 | |
 Migalastat hydrochloride |
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| B2404-25 | Biovision | EUR 756 | |
Migalastat hydrochloride |
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| B2404-5 | Biovision | EUR 229 | |
 Butenafine hydrochloride |
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| B2421-250 | Biovision | EUR 327 | |
Butenafine hydrochloride |
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| B2421-50 | Biovision | EUR 120 | |
 Naftifine hydrochloride |
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| B2422-10 | Biovision | EUR 131 | |
Naftifine hydrochloride |
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| B2422-50 | Biovision | EUR 349 | |
 Rilpivirine hydrochloride |
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| B2427-25 | Biovision | EUR 414 | |
Rilpivirine hydrochloride |
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| B2427-5 | Biovision | EUR 142 | |
 Tirabrutinib hydrochloride |
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| B2556-25 | Biovision | EUR 457 | |
Tirabrutinib hydrochloride |
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| B2556-5 | Biovision | EUR 153 | |
 Robenidine hydrochloride |
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| B2560-1G | Biovision | EUR 131 | |
Robenidine hydrochloride |
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| B2560-5G | Biovision | EUR 262 | |
 Sardomozide Hydrochloride |
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| B2566-25 | Biovision | EUR 631 | |
Sardomozide Hydrochloride |
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| B2566-5 | Biovision | EUR 196 | |
 Riviciclib hydrochloride |
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| B2567-1 | Biovision | EUR 142 | |
Riviciclib hydrochloride |
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| B2567-5 | Biovision | EUR 414 | |
) CPTH2 (hydrochloride) |
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| B2815-1 | Biovision | EUR 120 | |
CPTH2 (hydrochloride) |
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| B2815-5 | Biovision | EUR 294 | |
) Resminostat (hydrochloride) |
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| B2852-25 | Biovision | EUR 588 | |
Resminostat (hydrochloride) |
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| B2852-5 | Biovision | EUR 185 | |