objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.
method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.
result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.
conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.
Moxifloxacin Hydrochloride |
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| M033-100MG | TOKU-E | 100 mg | EUR 129 |
Moxifloxacin Hydrochloride |
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| M033-500MG | TOKU-E | 500 mg | EUR 424 |
Metformin hydrochloride |
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| M087-1G | TOKU-E | 1 g | EUR 47 |
Metformin hydrochloride |
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| M087-5G | TOKU-E | 5 g | EUR 52 |
Naftifine hydrochloride |
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| N047-500MG | TOKU-E | 500 mg | EUR 709 |
Naftifine hydrochloride |
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| N047-50MG | TOKU-E | 50 mg | EUR 138 |
Oxytetracycline Hydrochloride |
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| O004-100G | TOKU-E | 100 g | EUR 171 |
Oxytetracycline Hydrochloride |
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| O004-10G | TOKU-E | 10 g | EUR 66 |
Oxytetracycline Hydrochloride |
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| O004-50G | TOKU-E | 50 g | EUR 114 |
Ofloxacin Hydrochloride |
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| O039-10G | TOKU-E | 10g | EUR 163 |
Lomefloxacin hydrochloride |
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| L005-1G | TOKU-E | 1 g | EUR 74 |
Lomefloxacin hydrochloride |
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| L005-5G | TOKU-E | 5 g | EUR 153 |
Methacycline hydrochloride |
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| M003-100MG | TOKU-E | 100 mg | EUR 139 |
Methacycline hydrochloride |
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| M003-1G | TOKU-E | 1 g | EUR 187 |
Minocycline hydrochloride |
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| M008-1G | TOKU-E | 1 g | EUR 347 |
Minocycline hydrochloride |
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| M008-500MG | TOKU-E | 500 mg | EUR 200 |
Mitoxantrone hydrochloride |
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| M010-50MG | TOKU-E | 50 mg | EUR 129 |
Pirlimycin Hydrochloride |
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| P088-25MG | TOKU-E | 25 mg | EUR 670 |
Pirlimycin Hydrochloride |
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| P088-5MG | TOKU-E | 5 mg | EUR 213 |
Ofloxacin Hydrochloride |
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| O039-1G | TOKU-E | 1g | EUR 63 |
Tasidotin hydrochloride |
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| HY-13760 | MedChemExpress | 5mg | EUR 2198 |
Topotecan (Hydrochloride) |
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| HY-13768A | MedChemExpress | 10mg | EUR 119 |
Hydroxyfasudil (hydrochloride) |
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| HY-13911A | MedChemExpress | 10mM/1mL | EUR 168 |
Sevelamer hydrochloride |
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| HY-13995A | MedChemExpress | 100mg | EUR 153 |
Rimonabant (Hydrochloride) |
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| HY-14137 | MedChemExpress | 100mg | EUR 463 |
Cinaciguat (hydrochloride) |
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| HY-14181A | MedChemExpress | 50mg | EUR 1290 |
Vernakalant (Hydrochloride) |
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| HY-14183 | MedChemExpress | 5mg | EUR 366 |
Amiodarone (hydrochloride) |
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| HY-14188 | MedChemExpress | 500mg | EUR 108 |
Clorgyline hydrochloride |
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| HY-14197A | MedChemExpress | 100mg | EUR 380 |
Siramesine (hydrochloride) |
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| HY-14221A | MedChemExpress | 50mg | EUR 1290 |
Fadrozole hydrochloride |
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| HY-14247 | MedChemExpress | 100mg | EUR 614 |
Olprinone (Hydrochloride) |
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| HY-14254 | MedChemExpress | 50mg | EUR 452 |
Vilazodone (Hydrochloride) |
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| HY-14261 | MedChemExpress | 10mg | EUR 119 |
Tebanicline (hydrochloride) |
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| HY-14316A | MedChemExpress | 100mg | EUR 1069 |
Idalopirdine Hydrochloride |
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| HY-14338A | MedChemExpress | 50mg | EUR 1297 |
Haloperidol (hydrochloride) |
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| HY-14538A | MedChemExpress | 500mg | EUR 160 |
Ziprasidone (hydrochloride) |
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| HY-14542A | MedChemExpress | 50mg | EUR 277 |
Amisulpride (hydrochloride) |
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| HY-14545A | MedChemExpress | 100mg | EUR 160 |
Talnetant (hydrochloride) |
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| HY-14552A | MedChemExpress | 10mg | EUR 236 |
Idazoxan (hydrochloride) |
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| HY-14561A | MedChemExpress | 50mg | EUR 136 |
Pioglitazone (hydrochloride) |
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| HY-14601 | MedChemExpress | 100mg | EUR 119 |
MPEP (Hydrochloride) |
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| HY-14609 | MedChemExpress | 50mg | EUR 366 |
Diltiazem (hydrochloride) |
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| HY-14656 | MedChemExpress | 1g | EUR 119 |
CCT241533 (hydrochloride) |
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| HY-14715B | MedChemExpress | 100mg | EUR 1745 |
Resminostat (hydrochloride) |
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| HY-14718A | MedChemExpress | 10mM/1mL | EUR 307 |
Anamorelin (hydrochloride) |
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| HY-14734A | MedChemExpress | 5mg | EUR 147 |
Golotimod (hydrochloride) |
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| HY-14743B | MedChemExpress | 5mg | EUR 452 |
Cariprazine (hydrochloride) |
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| HY-14763A | MedChemExpress | 5mg | EUR 215 |
Imeglimin (hydrochloride) |
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| HY-14771A | MedChemExpress | 10mM/1mL | EUR 429 |
Befiradol (hydrochloride) |
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| HY-14785A | MedChemExpress | 10mM/1mL | EUR 744 |
Givinostat (hydrochloride) |
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| HY-14842A | MedChemExpress | 100mg | EUR 1703 |
Lasmiditan (hydrochloride) |
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| HY-14861A | MedChemExpress | 100mg | EUR 796 |
Omadacycline (hydrochloride) |
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| HY-14865C | MedChemExpress | 50mg | EUR 2116 |
Fabomotizole (hydrochloride) |
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| HY-14895A | MedChemExpress | 100mg | EUR 1714 |
Arbidol (hydrochloride) |
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| HY-14904A | MedChemExpress | 50mg | EUR 298 |
Migalastat (hydrochloride) |
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| HY-14929A | MedChemExpress | 25mg | EUR 587 |
Pardoprunox (hydrochloride) |
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| HY-14958A | MedChemExpress | 100mg | EUR 2943 |
R1487 (Hydrochloride) |
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| HY-14975 | MedChemExpress | 100mg | EUR 1139 |
Sinomenine hydrochloride |
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| HY-15122A | MedChemExpress | 100mg | EUR 119 |
Doxorubicin (hydrochloride) |
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| HY-15142 | MedChemExpress | 100mg | EUR 147 |
SBE13 (Hydrochloride) |
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| HY-15158 | MedChemExpress | 10mg | EUR 162 |
Icotinib (Hydrochloride) |
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| HY-15164 | MedChemExpress | 10mM/1mL | EUR 138 |
Pyridostatin (hydrochloride) |
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| HY-15176A | MedChemExpress | 10mg | EUR 195 |
Buparlisib (Hydrochloride) |
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| HY-15180 | MedChemExpress | 10mg | EUR 173 |
Agerafenib hydrochloride |
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| HY-15199 | MedChemExpress | 100mg | EUR 1703 |
EPZ004777 (hydrochloride) |
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| HY-15227A | MedChemExpress | 10mg | EUR 312 |
XL413 (hydrochloride) |
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| HY-15260A | MedChemExpress | 5mg | EUR 215 |
Prasugrel (hydrochloride) |
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| HY-15284A | MedChemExpress | 100mg | EUR 326 |
S107 hydrochloride |
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| HY-15292A | MedChemExpress | 50mg | EUR 670 |
CBB1007 (hydrochloride) |
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| HY-15313B | MedChemExpress | 100mg | EUR 1882 |
PRT062607 (Hydrochloride) |
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| HY-15323 | MedChemExpress | 10mM/1mL | EUR 229 |
Atrasentan (hydrochloride) |
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| HY-15403A | MedChemExpress | 10mM/1mL | EUR 349 |
Encenicline hydrochloride |
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| HY-15430A | MedChemExpress | 10mM/1mL | EUR 482 |
ZM323881 (hydrochloride) |
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| HY-15467A | MedChemExpress | 50mg | EUR 691 |
OTSSP167 (hydrochloride) |
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| HY-15512A | MedChemExpress | 50mg | EUR 1083 |
Piboserod (hydrochloride) |
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| HY-15574A | MedChemExpress | 50mg | EUR 670 |
MMAF (Hydrochloride) |
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| HY-15579A | MedChemExpress | 10mM/1mL | EUR 562 |
Taltobulin (hydrochloride) |
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| HY-15584B | MedChemExpress | 50mg | EUR 1025 |
AZD1208 hydrochloride |
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| HY-15604A | MedChemExpress | 10mg | EUR 167 |
MPTP (hydrochloride) |
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| HY-15608 | MedChemExpress | 50mg | EUR 257 |
SC144 (hydrochloride) |
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| HY-15614A | MedChemExpress | 25mg | EUR 245 |
SAR407899 (hydrochloride) |
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| HY-15687 | MedChemExpress | 10mM/1mL | EUR 126 |
SAR7334 (hydrochloride) |
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| HY-15699A | MedChemExpress | 10mM/1mL | EUR 475 |
Istaroxime (hydrochloride) |
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| HY-15718A | MedChemExpress | 50mg | EUR 1207 |
Afuresertib (hydrochloride) |
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| HY-15727A | MedChemExpress | 5mg | EUR 147 |
Dobutamine (hydrochloride) |
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| HY-15746 | MedChemExpress | 100mg | EUR 215 |
Deltarasin (hydrochloride) |
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| HY-15747A | MedChemExpress | 10mg | EUR 340 |
Ellipticine (hydrochloride) |
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| HY-15753A | MedChemExpress | 10mM/1mL | EUR 126 |
Tirabrutinib (hydrochloride) |
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| HY-15771A | MedChemExpress | 5mg | EUR 108 |
CBB1003 (hydrochloride) |
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| HY-15774A | MedChemExpress | 50mg | EUR 2116 |
Ribociclib hydrochloride |
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| HY-15777A | MedChemExpress | 10mM/1mL | EUR 141 |
K145 (hydrochloride) |
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| HY-15779A | MedChemExpress | 10mM/1mL | EUR 141 |
Ulixertinib (hydrochloride) |
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| HY-15816A | MedChemExpress | 100mg | EUR 567 |
GW311616 (hydrochloride) |
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| HY-15891A | MedChemExpress | 10mM/1mL | EUR 580 |
Ravoxertinib hydrochloride |
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| HY-15947A | MedChemExpress | 50mg | EUR 463 |
Uprosertib hydrochloride |
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| HY-15965A | MedChemExpress | 10mg | EUR 257 |
Ilorasertib (hydrochloride) |
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| HY-16018A | MedChemExpress | 10mM/1mL | EUR 196 |
Hexaminolevulinate (hydrochloride) |
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| HY-16045 | MedChemExpress | 100mg | EUR 119 |
Celgosivir (hydrochloride) |
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| HY-16134A | MedChemExpress | 50mg | EUR 2530 |
Forodesine (hydrochloride) |
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| HY-16209 | MedChemExpress | 2500ug | EUR 533 |
Kevetrin (hydrochloride) |
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| HY-16271 | MedChemExpress | 100mg | EUR 533 |
Metipranolol hydrochloride |
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| HY-16316 | MedChemExpress | 50mg | EUR 1025 |
Phenformin (hydrochloride) |
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| HY-16397A | MedChemExpress | 500mg | EUR 108 |
CNDAC (hydrochloride) |
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| HY-16445B | MedChemExpress | 10mM/1mL | EUR 492 |
Voreloxin (Hydrochloride) |
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| HY-16518 | MedChemExpress | 10mg | EUR 291 |
Riviciclib hydrochloride |
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| HY-16559 | MedChemExpress | 10mg | EUR 394 |
Irinotecan (hydrochloride) |
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| HY-16562A | MedChemExpress | 500mg | EUR 408 |
Asenapine (hydrochloride) |
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| HY-16567 | MedChemExpress | 10mM/1mL | EUR 126 |
Etifoxine (hydrochloride) |
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| HY-16579 | MedChemExpress | 50mg | EUR 441 |
Mofegiline (hydrochloride) |
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| HY-16677A | MedChemExpress | 5mg | EUR 181 |
Eltoprazine (hydrochloride) |
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| HY-16687A | MedChemExpress | 10mM/1mL | EUR 133 |
ZLN024 (hydrochloride) |
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| HY-16708A | MedChemExpress | 10mM/1mL | EUR 148 |
Amiselimod (hydrochloride) |
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| HY-16734A | MedChemExpress | 100mg | EUR 2460 |
Eleclazine (hydrochloride) |
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| HY-16738A | MedChemExpress | 10mM/1mL | EUR 529 |
Pexidartinib (hydrochloride) |
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| HY-16749A | MedChemExpress | 5mg | EUR 108 |
TH287 (hydrochloride) |
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| HY-16965A | MedChemExpress | 100mg | EUR 1153 |
SR9011 (hydrochloride) |
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| HY-16988A | MedChemExpress | 10mM/1mL | EUR 362 |
Miglustat (hydrochloride) |
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| HY-17020A | MedChemExpress | 25mg | EUR 567 |
Besifloxacin (Hydrochloride) |
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| HY-17028 | MedChemExpress | 50mg | EUR 326 |
Dexmedetomidine (hydrochloride) |
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| HY-17034A | MedChemExpress | 10mM/1mL | EUR 113 |
Medetomidine (hydrochloride) |
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| HY-17034B | MedChemExpress | 50mg | EUR 326 |
Agomelatine (hydrochloride) |
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| HY-17038A | MedChemExpress | 100mg | EUR 505 |
Vancomycin (hydrochloride) |
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| HY-17362 | MedChemExpress | 250mg | EUR 119 |
Idarubicin (hydrochloride) |
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| HY-17381 | MedChemExpress | 50mg | EUR 468 |
Atomoxetine (hydrochloride) |
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| HY-17385 | MedChemExpress | 100mg | EUR 155 |
Terbinafine hydrochloride |
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| HY-17395 | MedChemExpress | 200mg | EUR 172 |
Butenafine (Hydrochloride) |
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| HY-17396 | MedChemExpress | 5g | EUR 380 |
Iloperidone (hydrochloride) |
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| HY-17410A | MedChemExpress | 10mg | EUR 134 |
Minocycline (hydrochloride) |
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| HY-17412 | MedChemExpress | 100mg | EUR 133 |
Guanfacine (hydrochloride) |
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| HY-17416 | MedChemExpress | 100mg | EUR 408 |
Valacyclovir (hydrochloride) |
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| HY-17425A | MedChemExpress | 10mg | EUR 119 |
Tripelennamine (hydrochloride) |
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| HY-17428 | MedChemExpress | 10mM/1mL | EUR 156 |
Mefloquine (hydrochloride) |
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| HY-17437A | MedChemExpress | 500mg | EUR 186 |
Metformin (hydrochloride) |
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| HY-17471A | MedChemExpress | 10mM/1mL | EUR 113 |
Carteolol hydrochloride |
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| HY-17495A | MedChemExpress | 50mg | EUR 173 |
Acebutolol (hydrochloride) |
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| HY-17497A | MedChemExpress | 100mg | EUR 119 |
Bambuterol hydrochloride |
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| HY-17501A | MedChemExpress | 100mg | EUR 187 |
Meclofenoxate (hydrochloride) |
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| HY-17555 | MedChemExpress | 100mg | EUR 139 |
Demeclocycline (hydrochloride) |
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| HY-17560 | MedChemExpress | 10mM/1mL | EUR 134 |
Radafaxine (hydrochloride) |
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| HY-17590 | MedChemExpress | 10mM/1mL | EUR 179 |
S1RA (hydrochloride) |
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| HY-18099A | MedChemExpress | 10mM/1mL | EUR 580 |
Ombrabulin (hydrochloride) |
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| HY-18256 | MedChemExpress | 100mg | EUR 2943 |
Amitifadine (hydrochloride) |
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| HY-18332A | MedChemExpress | 50mg | EUR 2116 |
Conivaptan (hydrochloride) |
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| HY-18347A | MedChemExpress | 10mg | EUR 160 |
Diclofensine (hydrochloride) |
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| HY-18610 | MedChemExpress | 50mg | EUR 477 |
RS102895 (hydrochloride) |
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| HY-18611 | MedChemExpress | 50mg | EUR 573 |
Galidesivir (hydrochloride) |
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| HY-18649 | MedChemExpress | 5mg | EUR 2804 |
Endoxifen (hydrochloride) |
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| HY-18719B | MedChemExpress | 100mg | EUR 681 |
NSC305787 (hydrochloride) |
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| HY-18931A | MedChemExpress | 100mg | EUR 2943 |
CBL0137 hydrochloride |
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| HY-18935A | MedChemExpress | 25mg | EUR 693 |
Cilobradine (hydrochloride) |
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| HY-18940A | MedChemExpress | 2mg | EUR 601 |
Vatinoxan hydrochloride |
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| HY-19057A | MedChemExpress | 10mg | EUR 2002 |
Rimeporide hydrochloride |
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| HY-19273A | MedChemExpress | 1mg | EUR 268 |
AZD9056 (hydrochloride) |
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| HY-19427A | MedChemExpress | 25mg | EUR 544 |
BEC (hydrochloride) |
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| HY-19548A | MedChemExpress | 25mg | EUR 475 |
Ilginatinib hydrochloride |
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| HY-19631B | MedChemExpress | 10mM/1mL | EUR 356 |
Glesatinib (hydrochloride) |
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| HY-19642A | MedChemExpress | 25mg | EUR 1083 |
Pumosetrag Hydrochloride |
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| HY-19650 | MedChemExpress | 100mg | EUR 1703 |
Adriforant (hydrochloride) |
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| HY-19705B | MedChemExpress | 100mg | EUR 3229 |
Emixustat (hydrochloride) |
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| HY-19720A | MedChemExpress | 10mM/1mL | EUR 301 |
VU0357017 (hydrochloride) |
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| HY-19752A | MedChemExpress | 100mg | EUR 1153 |
ML241 (hydrochloride) |
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| HY-19797A | MedChemExpress | 100mg | EUR 1221 |
Vactosertib (Hydrochloride) |
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| HY-19928A | MedChemExpress | 100mg | EUR 1359 |
Clemizole (hydrochloride) |
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| HY-30234A | MedChemExpress | 100mg | EUR 712 |
Benzydamine (hydrochloride) |
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| HY-30235A | MedChemExpress | 100mg | EUR 119 |
Sultopride hydrochloride |
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| HY-42849A | MedChemExpress | 10mM/1mL | EUR 201 |
Mardepodect (hydrochloride) |
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| HY-50098A | MedChemExpress | 50mg | EUR 1139 |
Palbociclib (hydrochloride) |
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| HY-50767A | MedChemExpress | 200mg | EUR 243 |
Crizotinib (hydrochloride) |
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| HY-50878A | MedChemExpress | 10mg | EUR 119 |
Elacridar (hydrochloride) |
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| HY-50880 | MedChemExpress | 100mg | EUR 656 |
Gefitinib (hydrochloride) |
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| HY-50895A | MedChemExpress | 500mg | EUR 133 |
AT7519 (Hydrochloride) |
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| HY-50943 | MedChemExpress | 10mM/1mL | EUR 126 |
Moxifloxacin (Hydrochloride) |
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| HY-66011 | MedChemExpress | 100mg | EUR 160 |
Proparacaine (Hydrochloride) |
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| HY-66012 | MedChemExpress | 10mM/1mL | EUR 126 |
Cevimeline (hydrochloride) |
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| HY-70020B | MedChemExpress | 50mg | EUR 670 |
Cinacalcet (hydrochloride) |
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| HY-70037A | MedChemExpress | 10mg | EUR 160 |
Alosetron (Hydrochloride) |
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| HY-70050C | MedChemExpress | 100mg | EUR 371 |
Dronedarone (Hydrochloride) |
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| HY-75839 | MedChemExpress | 50mg | EUR 263 |
Dexrazoxane (hydrochloride) |
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| HY-76201 | MedChemExpress | 10mg | EUR 119 |
Cysteamine hydrochloride |
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| HY-77591 | MedChemExpress | 10mM/1mL | EUR 113 |
THZ1 (Hydrochloride) |
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| HY-80013A | MedChemExpress | 5mg | EUR 160 |
Lenalidomide (hydrochloride) |
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| HY-A0003A | MedChemExpress | 1g | EUR 340 |
Rotigotine (Hydrochloride) |
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| HY-A0007 | MedChemExpress | 50mg | EUR 257 |
Palonosetron (Hydrochloride) |
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| HY-A0021 | MedChemExpress | 50mg | EUR 133 |
Fenspiride (Hydrochloride) |
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| HY-A0027 | MedChemExpress | 10mM/1mL | EUR 156 |
Valganciclovir (hydrochloride) |
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| HY-A0032A | MedChemExpress | 50mg | EUR 201 |
Gabapentin (hydrochloride) |
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| HY-A0057A | MedChemExpress | 100mg | EUR 176 |
Tipiracil (hydrochloride) |
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| HY-A0063 | MedChemExpress | 50mg | EUR 257 |
Verapamil (hydrochloride) |
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| HY-A0064 | MedChemExpress | 10mM/1mL | EUR 113 |