Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.

objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.


method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.


result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.
Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.


conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.

TAME Hydrochloride

2050-500
EUR 338.00

Verapamil hydrochloride

2861-1G
EUR 131.00

Verapamil hydrochloride

2861-5G
EUR 327.00

Ticlopidine hydrochloride

2919-25
EUR 403.00

Ticlopidine hydrochloride

2919-5
EUR 153.00

EHNA hydrochloride

2265-25
EUR 283.00

EHNA hydrochloride

2265-5
EUR 115.00

AdipoRon hydrochloride

2572-25
EUR 588.00

AdipoRon hydrochloride

2572-5
EUR 185.00

Pargyline hydrochloride

2618-1000
EUR 175.00

Pargyline hydrochloride

2618-500
EUR 120.00

Clorgyline hydrochloride

2622-10
EUR 120.00

Clorgyline hydrochloride

2622-50
EUR 327.00

Clindamycin hydrochloride

2627-10
EUR 131.00

Clindamycin hydrochloride

2627-50
EUR 370.00

Loperamide hydrochloride

2683-1000
EUR 185.00

Loperamide hydrochloride

2683-500
EUR 131.00

Clonidine hydrochloride

2684-100
EUR 131.00

Clonidine hydrochloride

2684-500
EUR 359.00

Leelamine hydrochloride

2717-25
EUR 457.00

Leelamine hydrochloride

2717-5
EUR 153.00

SBE13 hydrochloride

2847-10
EUR 185.00

SBE13 hydrochloride

2847-50
EUR 588.00

Amodiaquine hydrochloride

A085-5G 5 g
EUR 55.00

Metformin, Hydrochloride

1691-5G
EUR 158.00

Irinotecan Hydrochloride

1752-250
EUR 387.00

Irinotecan Hydrochloride

1752-50
EUR 147.00

Epirubicin Hydrochloride

1753-25
EUR 457.00

Epirubicin Hydrochloride

1753-5
EUR 158.00

Gemcitabine Hydrochloride

1759-100
EUR 370.00

Gemcitabine Hydrochloride

1759-25
EUR 156.00

Amiodarone Hydrochloride

1828-100
EUR 126.00

Amiodarone Hydrochloride

1828-500
EUR 338.00

Phenformin hydrochloride

1889-100
EUR 115.00

Phenformin hydrochloride

1889-1000
EUR 359.00

Tomatidine hydrochloride

1893-25
EUR 137.00

Vancomycin Hydrochloride

B1507-1G
EUR 153.00

Vancomycin Hydrochloride

B1507-250
EUR 120.00

Vancomycin Hydrochloride

B1507-5G
EUR 262.00

Lincomycin Hydrochloride

B1524-1G
EUR 142.00

Lincomycin Hydrochloride

B1524-5G
EUR 403.00

Minocycline Hydrochloride

B1525-250
EUR 414.00

Minocycline Hydrochloride

B1525-50
EUR 142.00

Oxytetracycline Hydrochloride

B1527-25G
EUR 229.00

Oxytetracycline Hydrochloride

B1527-5G
EUR 109.00

Tetracycline Hydrochloride

B1535-10G
EUR 109.00

Tetracycline Hydrochloride

B1535-50G
EUR 196.00

Hydroxyfasudil Hydrochloride

B1559-25
EUR 631.00

Hydroxyfasudil Hydrochloride

B1559-5
EUR 196.00

Thioridazine Hydrochloride

B1581-1G
EUR 120.00

Thioridazine Hydrochloride

B1581-5G
EUR 327.00

Ivabradine Hydrochloride

B1595-10
EUR 142.00

Bendamustine Hydrochloride

B1596-25
EUR 457.00

Bendamustine Hydrochloride

B1596-5
EUR 153.00

Afuresertib hydrochloride

B1848-5
EUR 175.00

Chlorpromazine hydrochloride

B1992-100
EUR 120.00

Chlorpromazine hydrochloride

B1992-500
EUR 294.00

Triflupromazine hydrochloride

B1993-100
EUR 120.00

 ZLN024 hydrochloride

B2034-25
EUR 588.00

 ZLN024 hydrochloride

B2034-5
EUR 185.00

Topotecan hydrochloride

B2050-10
EUR 131.00

Givinostat hydrochloride

B2081-25
EUR 756.00

Givinostat hydrochloride

B2081-5
EUR 229.00

Moexipril hydrochloride

B2134-25
EUR 294.00

Imidapril hydrochloride

B2135-25
EUR 414.00

Imidapril hydrochloride

B2135-5
EUR 142.00

Benazepril hydrochloride

B2138-250
EUR 294.00

Benazepril hydrochloride

B2138-50
EUR 131.00

Dorzolamide hydrochloride

B2185-10
EUR 120.00

Dorzolamide hydrochloride

B2185-50
EUR 327.00

Eltoprazine hydrochloride

B2301-25
EUR 457.00

Eltoprazine hydrochloride

B2301-5
EUR 153.00

Papaverine hydrochloride

B2315-250
EUR 262.00

Papaverine hydrochloride

B2315-50
EUR 120.00

Sarecycline hydrochloride

B2383-25
EUR 588.00

Sarecycline hydrochloride

B2383-5
EUR 185.00

Sertraline (hydrochloride)

B2393-10
EUR 131.00

Sertraline (hydrochloride)

B2393-50
EUR 327.00

Migalastat hydrochloride

B2404-25
EUR 756.00

Migalastat hydrochloride

B2404-5
EUR 229.00

Butenafine hydrochloride

B2421-250
EUR 327.00

Butenafine hydrochloride

B2421-50
EUR 120.00

Naftifine hydrochloride

B2422-10
EUR 131.00

Naftifine hydrochloride

B2422-50
EUR 349.00

Rilpivirine hydrochloride

B2427-25
EUR 414.00

Rilpivirine hydrochloride

B2427-5
EUR 142.00

Tirabrutinib hydrochloride

B2556-25
EUR 457.00

Tirabrutinib hydrochloride

B2556-5
EUR 153.00

Robenidine hydrochloride

B2560-1G
EUR 131.00

Robenidine hydrochloride

B2560-5G
EUR 262.00

Sardomozide Hydrochloride

B2566-25
EUR 631.00

Sardomozide Hydrochloride

B2566-5
EUR 196.00

Riviciclib hydrochloride

B2567-1
EUR 142.00

Riviciclib hydrochloride

B2567-5
EUR 414.00

CPTH2 (hydrochloride)

B2815-1
EUR 120.00

CPTH2 (hydrochloride)

B2815-5
EUR 294.00

Resminostat (hydrochloride)

B2852-25
EUR 588.00

Resminostat (hydrochloride)

B2852-5
EUR 185.00

Almorexant hydrochloride

B3241-10 10 mg
EUR 440.00
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Almorexant hydrochloride

B3241-5 5 mg
EUR 270.00
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Memantine hydrochloride

B3308-200 200 mg
EUR 137.00
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-S Evaluation Sample
EUR 81.00
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Cyproheptadine hydrochloride

B3309-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-50 50 mg
EUR 128.00
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-S Evaluation Sample
EUR 81.00
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Moxonidine hydrochloride

B3314-10 10 mg
EUR 195.00
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-100 100 mg
EUR 864.00
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-50 50 mg
EUR 502.00
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Bupropion hydrochloride

B3326-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-50 50 mg
EUR 128.00
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-S Evaluation Sample
EUR 81.00
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Sotalol hydrochloride

B3341-100 100 mg
EUR 139.00
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-200 200 mg
EUR 187.00
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-5.1 10 mM (in 1mL DMSO)
EUR 119.00
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-50 50 mg
EUR 106.00
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-S Evaluation Sample
EUR 81.00
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Miglustat hydrochloride

B3402-10 10 mg
EUR 312.00
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Miglustat hydrochloride

B3402-25 25 mg
EUR 641.00
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Miglustat hydrochloride

B3402-5 5 mg
EUR 195.00
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Solifenacin hydrochloride

B3415-10 10 mg
EUR 321.00
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-100 100 mg
EUR 1407.00
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-5 5 mg
EUR 231.00
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-5.1 10 mM (in 1mL DMSO)
EUR 248.00
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-50 50 mg
EUR 864.00
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Vigabatrin Hydrochloride

B3421-10 10 mg
EUR 142.00
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Vigabatrin Hydrochloride

B3421-25 25 mg
EUR 270.00
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Vigabatrin Hydrochloride

B3421-50 50 mg
EUR 440.00
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Flavoxate hydrochloride

B3433-5 5 mg
EUR 131.00
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Flavoxate hydrochloride

B3433-5.1 10 mM (in 1mL DMSO)
EUR 166.00
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Flavoxate hydrochloride

B3433-50 50 mg
EUR 363.00
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Tiagabine hydrochloride

B3443-10 10 mg
EUR 102.00

Tiagabine hydrochloride

B3443-5.1 10 mM (in 1mL DMSO)
EUR 108.00

Lercanidipine hydrochloride

B3482-10 10 mg
EUR 119.00

Lercanidipine hydrochloride

B3482-100 100 mg
EUR 453.00

Lercanidipine hydrochloride

B3482-200 200 mg
EUR 592.00

Lercanidipine hydrochloride

B3482-5.1 10 mM (in 1mL DMSO)
EUR 132.00

Lercanidipine hydrochloride

B3482-50 50 mg
EUR 313.00

Sarpogrelate hydrochloride

B3494-10 10 mg
EUR 139.00
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-100 100 mg
EUR 421.00
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-5.1 10 mM (in 1mL DMSO)
EUR 150.00
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-50 50 mg
EUR 322.00
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Ramosetron Hydrochloride

B3536-10 10 mg
EUR 126.00

Ramosetron Hydrochloride

B3536-100 100 mg
EUR 661.00

Ramosetron Hydrochloride

B3536-25 25 mg
EUR 222.00

Ramosetron Hydrochloride

B3536-50 50 mg
EUR 376.00

Demeclocycline hydrochloride

B3601-1000 1 g
EUR 174.00

Demeclocycline hydrochloride

B3601-500 500 mg
EUR 145.00

Crizotinib hydrochloride

B3608-10 10 mg
EUR 139.00

Crizotinib hydrochloride

B3608-100 100 mg
EUR 303.00

Crizotinib hydrochloride

B3608-200 200 mg
EUR 485.00

Crizotinib hydrochloride

B3608-5.1 10 mM (in 1mL DMSO)
EUR 150.00

Crizotinib hydrochloride

B3608-50 50 mg
EUR 231.00

Crizotinib hydrochloride

B3608-500 500 mg
EUR 756.00

GW311616 hydrochloride

B4676-10 10 mg
EUR 601.00
Description: GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].

GW311616 hydrochloride

B4676-100 100 mg
EUR 2364.00
Description: GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].

GW311616 hydrochloride

B4676-5 5 mg
EUR 435.00
Description: GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].

GW311616 hydrochloride

B4676-5.1 10 mM (in 1mL DMSO)
EUR 583.00
Description: GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].

GW311616 hydrochloride

B4676-50 50 mg
EUR 1703.00
Description: GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].

THZ1 Hydrochloride

B4736-10 10 mg
EUR 224.00
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-25 25 mg
EUR 398.00
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-5 5 mg
EUR 142.00
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-5.1 10 mM (in 1mL DMSO)
EUR 171.00
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

ZLN024 hydrochloride

B4840-10 10 mg
EUR 248.00

ZLN024 hydrochloride

B4840-5 5 mg
EUR 167.00

ZLN024 hydrochloride

B4840-50 50 mg
EUR 864.00

SAR407899 hydrochloride

B4909-10 10 mg
EUR 200.00

SAR407899 hydrochloride

B4909-100 100 mg
EUR 773.00

SAR407899 hydrochloride

B4909-5 5 mg
EUR 139.00

SAR407899 hydrochloride

B4909-5.1 10 mM (in 1mL DMSO)
EUR 150.00

SAR407899 hydrochloride

B4909-50 50 mg
EUR 502.00

Pronethalol hydrochloride

B5023-100 100 mg
EUR 210.00

Dihydrexidine hydrochloride

B5028-25 25 mg
EUR 1054.00

Dihydrexidine hydrochloride

B5028-5 5 mg
EUR 292.00

Norketamine hydrochloride

B5244-10 10 mg
EUR 226.00

Norketamine hydrochloride

B5244-50 50 mg
EUR 796.00

(+)-Igmesine hydrochloride

B5294-10 10 mg
EUR 486.00
Description: IC50: 19.1 nMJO 1784 is a selective ?1 receptor ligand.The CNS ? receptor ligands, as is known, modulates central neurotransmitter systems ( noradrenergic-, glutaminergic-, and dopaminergic-neurons was included).

(+)-Igmesine hydrochloride

B5294-50 50 mg
EUR 1850.00
Description: IC50: 19.1 nMJO 1784 is a selective ?1 receptor ligand.The CNS ? receptor ligands, as is known, modulates central neurotransmitter systems ( noradrenergic-, glutaminergic-, and dopaminergic-neurons was included).

DOI hydrochloride

B5321-10 10 mg
EUR 171.00

DOI hydrochloride

B5321-5 5 mg
EUR 118.00

DOI hydrochloride

B5321-50 50 mg
EUR 595.00

DOB hydrochloride

B5344-1 1 mg
EUR 118.00

Tropisetron Hydrochloride

B1002-1000 1 g
EUR 224.00
Description: Tropisetron is a selective 5-HT3 receptor antagonist and ?7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

Tropisetron Hydrochloride

B1002-500 500 mg
EUR 171.00
Description: Tropisetron is a selective 5-HT3 receptor antagonist and ?7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

XL413 hydrochloride

B1015-10 10 mg
EUR 241.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-100 100 mg
EUR 838.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-5 5 mg
EUR 171.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-50 50 mg
EUR 595.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

Imeglimin hydrochloride

B1067-10 10 mg
EUR 490.00
Description: AMP-activated protein kinase (AMPK) acts as an integrator of regulatory signals to monitor systemic and cellular energy status.

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