Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.

objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.


method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.


result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.
Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.


conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.

Amsacrine hydrochloride

B1303-1000 1 g
EUR 711.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

Amsacrine hydrochloride

B1303-200 200 mg
EUR 402.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

Amsacrine hydrochloride

B1303-25 25 mg
EUR 181.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

Amsacrine hydrochloride

B1303-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

Amsacrine hydrochloride

B1303-50 50 mg
EUR 226.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

Amsacrine hydrochloride

B1303-500 500 mg
EUR 601.00
Description: Amsacrine hydrochloride (Amsidine, m-AMSA) is an inhibitor of topoisomerase 2 [1].Amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia

OTSSP167 hydrochloride

B1308-1 1 mg
EUR 118.00
Description: OTSSP167 is an inhibitor of maternal embryonic leucine zipper kinase(MELK) with IC50 value of 0.41nM [1].MELK belongs to the AMPK serine/threonine kinase family and involves in the mammalian embryonic development.

OTSSP167 hydrochloride

B1308-10 10 mg
EUR 595.00
Description: OTSSP167 is an inhibitor of maternal embryonic leucine zipper kinase(MELK) with IC50 value of 0.41nM [1].MELK belongs to the AMPK serine/threonine kinase family and involves in the mammalian embryonic development.

SHP099 hydrochloride

B1308-25
EUR 588.00

OTSSP167 hydrochloride

B1308-5 5 mg
EUR 357.00
Description: OTSSP167 is an inhibitor of maternal embryonic leucine zipper kinase(MELK) with IC50 value of 0.41nM [1].MELK belongs to the AMPK serine/threonine kinase family and involves in the mammalian embryonic development.

Vancomycin Hydrochloride

B1507-1G
EUR 153.00

Vancomycin Hydrochloride

B1507-250
EUR 120.00

Vancomycin Hydrochloride

B1507-5G
EUR 262.00

Lincomycin Hydrochloride

B1524-1G
EUR 142.00

Lincomycin Hydrochloride

B1524-5G
EUR 403.00

Minocycline Hydrochloride

B1525-250
EUR 414.00

Minocycline Hydrochloride

B1525-50
EUR 142.00

Oxytetracycline Hydrochloride

B1527-25G
EUR 229.00

Oxytetracycline Hydrochloride

B1527-5G
EUR 109.00

Tetracycline Hydrochloride

B1535-10G
EUR 109.00

Tetracycline Hydrochloride

B1535-50G
EUR 196.00

Hydroxyfasudil Hydrochloride

B1559-25
EUR 631.00

Hydroxyfasudil Hydrochloride

B1559-5
EUR 196.00

Tropisetron Hydrochloride

B1002-1000 1 g
EUR 224.00
Description: Tropisetron is a selective 5-HT3 receptor antagonist and ?7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

Tropisetron Hydrochloride

B1002-500 500 mg
EUR 171.00
Description: Tropisetron is a selective 5-HT3 receptor antagonist and ?7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

XL413 hydrochloride

B1015-10 10 mg
EUR 241.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-100 100 mg
EUR 838.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-5 5 mg
EUR 171.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-50 50 mg
EUR 595.00
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

Imeglimin hydrochloride

B1067-10 10 mg
EUR 490.00
Description: AMP-activated protein kinase (AMPK) acts as an integrator of regulatory signals to monitor systemic and cellular energy status.

Imeglimin hydrochloride

B1067-100 100 mg
EUR 1674.00
Description: AMP-activated protein kinase (AMPK) acts as an integrator of regulatory signals to monitor systemic and cellular energy status.

Imeglimin hydrochloride

B1067-5 5 mg
EUR 340.00
Description: AMP-activated protein kinase (AMPK) acts as an integrator of regulatory signals to monitor systemic and cellular energy status.

Imeglimin hydrochloride

B1067-50 50 mg
EUR 1094.00
Description: AMP-activated protein kinase (AMPK) acts as an integrator of regulatory signals to monitor systemic and cellular energy status.

Kevetrin hydrochloride

B1068-10
EUR 142.00

Kevetrin hydrochloride

B1068-50
EUR 414.00

Cefoselis hydrochloride

B1075-10 10 mg
EUR 354.00
Description: Cefoselis is a widely used beta-lactam antibiotic.

Cefoselis hydrochloride

B1075-100 100 mg
EUR 1299.00
Description: Cefoselis is a widely used beta-lactam antibiotic.

Cefoselis hydrochloride

B1075-5 5 mg
EUR 239.00
Description: Cefoselis is a widely used beta-lactam antibiotic.

Cefoselis hydrochloride

B1075-50 50 mg
EUR 831.00
Description: Cefoselis is a widely used beta-lactam antibiotic.

Cephalexin hydrochloride

B1077-1000 1 g
EUR 139.00
Description: Cefalexin hydrochloride is a cephalosporin antibiotic.

Cephalexin hydrochloride

B1077-5000 5 g
EUR 195.00
Description: Cefalexin hydrochloride is a cephalosporin antibiotic.

LEE011 hydrochloride

B1083-10 10 mg
EUR 195.00
Description: LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 hydrochloride

B1083-100 100 mg
EUR 502.00
Description: LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 hydrochloride

B1083-5 5 mg
EUR 158.00
Description: LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 hydrochloride

B1083-5.1 10 mM (in 1mL DMSO)
EUR 168.00
Description: LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 hydrochloride

B1083-50 50 mg
EUR 321.00
Description: LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

Cytarabine hydrochloride

B1100-1000 1 g
EUR 224.00
Description: Cytarabine hydrochloride is an effective drug in the treatment of cancers of white blood cells [1].Cytarabine hydrochloride is a dxoxycytidine (dC) analogue.

Cytarabine hydrochloride

B1100-200 200 mg
EUR 108.00
Description: Cytarabine hydrochloride is an effective drug in the treatment of cancers of white blood cells [1].Cytarabine hydrochloride is a dxoxycytidine (dC) analogue.

GSK962040 hydrochloride

B1137-10 10 mg
EUR 954.00
Description: GSK962040 is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.

GSK962040 hydrochloride

B1137-100 100 mg
EUR 3850.00
Description: GSK962040 is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.

GSK962040 hydrochloride

B1137-5 5 mg
EUR 683.00
Description: GSK962040 is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.

GSK962040 hydrochloride

B1137-50 50 mg
EUR 2764.00
Description: GSK962040 is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.

Varenicline Hydrochloride

B1141-10 10 mg
EUR 231.00
Description: Varenicline Hydrochloride is a partial agonist of ?4?2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for ?6?2* nAChR and ?4?2* nAChR

Varenicline Hydrochloride

B1141-100 100 mg
EUR 954.00
Description: Varenicline Hydrochloride is a partial agonist of ?4?2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for ?6?2* nAChR and ?4?2* nAChR

Varenicline Hydrochloride

B1141-25 25 mg
EUR 393.00
Description: Varenicline Hydrochloride is a partial agonist of ?4?2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for ?6?2* nAChR and ?4?2* nAChR

Triclopidine hydrochloride

B1141-250
EUR 294.00

Varenicline Hydrochloride

B1141-5 5 mg
EUR 176.00
Description: Varenicline Hydrochloride is a partial agonist of ?4?2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for ?6?2* nAChR and ?4?2* nAChR

Varenicline Hydrochloride

B1141-50 50 mg
EUR 592.00
Description: Varenicline Hydrochloride is a partial agonist of ?4?2 nicotinic receptor for smoking cessation [1].Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for ?6?2* nAChR and ?4?2* nAChR

MPEP hydrochloride

B1151-10
EUR 185.00

MPEP hydrochloride

B1151-50
EUR 588.00

Meclofenoxate hydrochloride

B1160-100 100 mg
EUR 158.00
Description: Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.

Meclofenoxate hydrochloride

B1160-5.1 10 mM (in 1mL DMSO)
EUR 179.00
Description: Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.

Pimobendan hydrochloride

B1165-10 10 mg
EUR 512.00
Description: Pimobendan hydrochloride is a selective inhibitor of PDE3 with IC50 of 0.32 ?M.

Pimobendan hydrochloride

B1165-5 5 mg
EUR 296.00
Description: Pimobendan hydrochloride is a selective inhibitor of PDE3 with IC50 of 0.32 ?M.

Pimobendan hydrochloride

B1165-50 50 mg
EUR 1453.00
Description: Pimobendan hydrochloride is a selective inhibitor of PDE3 with IC50 of 0.32 ?M.

Nafamostat hydrochloride

B1178-10 10 mg
EUR 139.00
Description: Nafamostat hydrochloride, a synthetic serine protease inhibitor, is an anticoagulant.

Nafamostat hydrochloride

B1178-50 50 mg
EUR 321.00
Description: Nafamostat hydrochloride, a synthetic serine protease inhibitor, is an anticoagulant.

S1RA hydrochloride

B1180-10 10 mg
EUR 954.00
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-100 100 mg
EUR 3850.00
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-5 5 mg
EUR 683.00
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-5.1 10 mM (in 1mL DMSO)
EUR 746.00
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-50 50 mg
EUR 2764.00
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

Imiquimod hydrochloride

B1186-100 100 mg
EUR 108.00
Description: Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.

SAR7334 hydrochloride

B1189-5 5 mg
EUR 470.00
Description: SAR7334 hydrochloride is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor.

Iloperidone hydrochloride

B1203-10 10 mg
EUR 161.00
Description: Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.

Iloperidone hydrochloride

B1203-100 100 mg
EUR 846.00
Description: Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.

Iloperidone hydrochloride

B1203-50 50 mg
EUR 485.00
Description: Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.

Gatifloxacin hydrochloride

B1215-1000 1 g
EUR 139.00
Description: Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Gatifloxacin hydrochloride

B1215-5000 5 g
EUR 321.00
Description: Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Tigecycline hydrochloride

B1219-10 10 mg
EUR 212.00
Description: Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Tigecycline hydrochloride

B1219-100 100 mg
EUR 592.00
Description: Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Tigecycline hydrochloride

B1219-200 200 mg
EUR 809.00
Description: Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Tigecycline hydrochloride

B1219-50 50 mg
EUR 340.00
Description: Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Tigecycline hydrochloride

B1219-500 500 mg
EUR 991.00
Description: Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Norfloxacin hydrochloride

B1221-10 10 mg
EUR 160.00
Description: Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Norfloxacin hydrochloride

B1221-5 5 mg
EUR 116.00
Description: Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Norfloxacin hydrochloride

B1221-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Vancomycin hydrochloride

B1223-100 100 mg
EUR 232.00
Description: Vancomycin hydrochloride is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.

Vancomycin hydrochloride

B1223-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Vancomycin hydrochloride is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.

Haloperidol hydrochloride

B1242-1000 1 g
EUR 209.00
Description: Haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].Haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine.

Haloperidol hydrochloride

B1242-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].Haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine.

Haloperidol hydrochloride

B1242-500 500 mg
EUR 134.00
Description: Haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].Haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine.

Etomidate hydrochloride

B1246-100 100 mg
EUR 340.00
Description: Etomidate is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Etomidate hydrochloride

B1246-25 25 mg
EUR 166.00
Description: Etomidate is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Etomidate hydrochloride

B1246-5 5 mg
EUR 108.00
Description: Etomidate is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Etomidate hydrochloride

B1246-5.1 10 mM (in 1mL DMSO)
EUR 142.00
Description: Etomidate is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Ezatiostat hydrochloride

B1250-10 10 mg
EUR 197.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Ezatiostat hydrochloride

B1250-100 100 mg
EUR 799.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Ezatiostat hydrochloride

B1250-25 25 mg
EUR 292.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Ezatiostat hydrochloride

B1250-5 5 mg
EUR 138.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Ezatiostat hydrochloride

B1250-5.1 10 mM (in 1mL DMSO)
EUR 212.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Ezatiostat hydrochloride

B1250-50 50 mg
EUR 490.00
Description: Ezatiostat hydrochloride(TLK199) is an effective inhibitor of glutathione S-transferase ?GST?[1].Ezatiostat hydrochloride (TLK199) is a novel glutathione analog and the potential treatment of cytopenias.

Deltarasin hydrochloride

B1261-1 1 mg
EUR 116.00
Description: Deltarasin hydrochloride is a selective inhibitor of KRAS-PDE? interaction with IC50 value of 41±12 nM [1]. KRAS is a protein and works as a molecular on/off switch whose mutant is an essential step in the development of many cancers.

Deltarasin hydrochloride

B1261-10 10 mg
EUR 450.00
Description: Deltarasin hydrochloride is a selective inhibitor of KRAS-PDE? interaction with IC50 value of 41±12 nM [1]. KRAS is a protein and works as a molecular on/off switch whose mutant is an essential step in the development of many cancers.

Deltarasin hydrochloride

B1261-5 5 mg
EUR 316.00
Description: Deltarasin hydrochloride is a selective inhibitor of KRAS-PDE? interaction with IC50 value of 41±12 nM [1]. KRAS is a protein and works as a molecular on/off switch whose mutant is an essential step in the development of many cancers.

Reserpine hydrochloride

B1270-20 20 mg
EUR 137.00
Description: Reserpine hydrochloride (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).

Reserpine hydrochloride

B1270-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Reserpine hydrochloride (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).

Prilocaine hydrochloride

B1280-10 10 mg
EUR 96.00
Description: Prilocaine hydrochloride is a local anesthetic of the amino amide type.

Prilocaine hydrochloride

B1280-1000 1 g
EUR 108.00
Description: Prilocaine hydrochloride is a local anesthetic of the amino amide type.

Prilocaine hydrochloride

B1280-10000 10 g
EUR 328.00
Description: Prilocaine hydrochloride is a local anesthetic of the amino amide type.

Prilocaine hydrochloride

B1280-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Prilocaine hydrochloride is a local anesthetic of the amino amide type.

Prilocaine hydrochloride

B1280-5000 5 g
EUR 224.00
Description: Prilocaine hydrochloride is a local anesthetic of the amino amide type.

Prasugrel hydrochloride

B1283-100 100 mg
EUR 131.00
Description: Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 ?M.

Prasugrel hydrochloride

B1283-5 5 mg
EUR 108.00
Description: Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 ?M.

Prasugrel hydrochloride

B1283-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 ?M.

Tetracycline, Hydrochloride

CH054 25 g
EUR 119.00

Tetracycline, Hydrochloride

CH055 100 g
EUR 170.00

Nortriptyline (hydrochloride)

C4077-100 100 mg
EUR 163.00
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)

C4077-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)

C4077-50 50 mg
EUR 116.00
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Imipramine (hydrochloride)

C4117-5.1 10 mM (in 1mL H2O)
EUR 113.00
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Imipramine (hydrochloride)

C4117-5000 5 g
EUR 108.00
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Clorgyline (hydrochloride)

C4137-100 100 mg
EUR 224.00
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)

C4137-25 25 mg
EUR 110.00
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)

C4137-50 50 mg
EUR 154.00
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Doxepin (hydrochloride)

C4153-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (hydrochloride)

C4153-5000 5 g
EUR 168.00
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Anhydrochlortetracycline (hydrochloride)

C4218-1 1 mg
EUR 132.00
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrochlortetracycline (hydrochloride)

C4218-5 5 mg
EUR 255.00
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrotetracycline (hydrochloride)

C4291-100 100 mg
EUR 241.00
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)

C4291-25 25 mg
EUR 123.00
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)

C4291-50 50 mg
EUR 171.00
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Kanosamine (hydrochloride)

C3461-10 10 mg
EUR 440.00
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)

C3461-25 25 mg
EUR 908.00
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)

C3461-5 5 mg
EUR 270.00
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Zoniporide (hydrochloride)

C3480-10 10 mg
EUR 232.00
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)

C3480-5 5 mg
EUR 151.00
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)

C3480-50 50 mg
EUR 837.00
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

MS023 (hydrochloride)

C3503-1 1 mg
EUR 112.00
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-10 10 mg
EUR 551.00
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-25 25 mg
EUR 1146.00
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-5 5 mg
EUR 332.00
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

Chlorprothixene (hydrochloride)

C3509-1000 1 g
EUR 86.00
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-10000 10 g
EUR 331.00
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-25000 25 g
EUR 664.00
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-5000 5 g
EUR 208.00
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Celiprolol (hydrochloride)

C4521-10 10 mg
EUR 254.00
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-25 25 mg
EUR 500.00
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-5 5 mg
EUR 183.00
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)

C4635-1000 1 g
EUR 328.00

Aceclidine (hydrochloride)

C4635-500 500 mg
EUR 206.00

Ulixertinib (hydrochloride)

C3921-10 10 mg
EUR 406.00
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-25 25 mg
EUR 661.00
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-5 5 mg
EUR 250.00
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Chlorcyclizine (hydrochloride)

C3989-100 100 mg
EUR 118.00
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-1000 1 g
EUR 595.00
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-250 250 mg
EUR 210.00
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-500 500 mg
EUR 357.00
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Lofexidine (hydrochloride)

C3990-1000 1 g
EUR 126.00
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)

C3990-5.1 10 mM (in 1mL H2O)
EUR 113.00
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)

C3990-500 500 mg
EUR 100.00
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

(±)-Salsolinol (hydrochloride)

C4364-500 500 mg
EUR 308.00
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)

C4493-100 100 mg
EUR 113.00
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)

C4493-250 250 mg
EUR 200.00
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Trimidox (hydrochloride)

C4714-10 10 mg
EUR 184.00
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-25 25 mg
EUR 370.00
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-5 5 mg
EUR 121.00
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-50 50 mg
EUR 618.00
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

VU590 (hydrochloride)

C4778-10 10 mg
EUR 195.00

VU590 (hydrochloride)

C4778-25 25 mg
EUR 389.00

VU590 (hydrochloride)

C4778-5 5 mg
EUR 139.00

MS049 (hydrochloride)

C3776-10 10 mg
EUR 200.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-100 100 mg
EUR 1181.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-25 25 mg
EUR 382.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5 5 mg
EUR 139.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5.1 10 mM (in 1mL DMSO)
EUR 150.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-50 50 mg
EUR 653.00
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

Guanabenz (hydrochloride)

C3786-100 100 mg
EUR 231.00
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Guanabenz (hydrochloride)

C3786-50 50 mg
EUR 144.00
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Stachydrine (hydrochloride)

C3648-100 100 mg
EUR 119.00
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-1000 1 g
EUR 467.00
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-250 250 mg
EUR 206.00
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-500 500 mg
EUR 328.00
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Barnidipine (hydrochloride)

C3727-100 100 mg
EUR 203.00
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Barnidipine (hydrochloride)

C3727-50 50 mg
EUR 155.00
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Naloxone (hydrochloride)

B8208-100 100 mg
EUR 113.00

Betaine hydrochloride

BB0133 250g
EUR 75.52
  • Product category: Biochemicals/Misc. Biochemicals

Rimantadine Hydrochloride

B7849-25 25 mg
EUR 128.00
Description: Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.In a variety of tissue culture systems, rimantadine (25 ?g/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL).

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