Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.

objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.


method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.


result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.
Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.


conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.

TRIS hydrochloride

GB4431-500G 500 g
EUR 103.2

TRIS hydrochloride

GB4431-5KG 5 kg
EUR 486

Tris hydrochloride

TB0103 250g
EUR 84.01

TRIS hydrochloride

GB4431-1 1
EUR 102.7

TRIS hydrochloride

GB4431-100 100
EUR 23.8

TRIS hydrochloride

GB4431-250 250
EUR 34.1

TRIS hydrochloride

GB4431-5 5
EUR 371.8

TRIS hydrochloride

GB4431-500 500
EUR 55.4

Trimidox (hydrochloride)

C4714-10 10 mg
EUR 220.8
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-25 25 mg
EUR 444
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-5 5 mg
EUR 145.2
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-50 50 mg
EUR 741.6
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trilaciclib hydrochloride

HY-101467A 10mM/1mL
EUR 1162.8

Triclopidine hydrochloride

B1141-250 each
EUR 352.8

Trigonelline Hydrochloride

N2577-20 20 mg
EUR 129.6
Description: Extracted from Trigonellafoenum-graecumL. seeds;Store the product in sealed, cool and dry condition

Trigonelline Hydrochloride

N2577-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Extracted from Trigonellafoenum-graecumL. seeds;Store the product in sealed, cool and dry condition

Trigonelline hydrochloride

TB0720-0500 8XX20mg
EUR 328.8

Trigonelline hydrochloride

GK5203-100 100
EUR 44.8

2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE)

101003 each Ask for price

Triethylamine hydrochloride

GK0316-100G 100 g
EUR 64.8

Triethylamine hydrochloride

GK0316-1KG 1 kg
EUR 132

Triethylamine hydrochloride

GK0316-1 1
EUR 79.1

Triethylamine hydrochloride

GK0316-100 100
EUR 23.8

Tripelennamine (hydrochloride)

HY-17428 10mM/1mL
EUR 187.2

Triacetonamine hydrochloride

TB01047 unit Ask for price

Triflupromazine hydrochloride

B1993-100 each
EUR 144

Trihexyphenidyl hydrochloride

B6130-1000 1 g
EUR 160.8

Trihexyphenidyl hydrochloride

B6130-5.1 10 mM (in 1mL DMSO)
EUR 180

Triflupromazine (hydrochloride)

HY-B0909 100mg
EUR 142.8

Trihexyphenidyl (hydrochloride)

HY-B1277 500mg
EUR 129.6

DOI hydrochloride

B5321-10 10 mg
EUR 205.2

DOI hydrochloride

B5321-5 5 mg
EUR 141.6

DOI hydrochloride

B5321-50 50 mg
EUR 714

DOB hydrochloride

B5344-1 1 mg
EUR 141.6

Q94 hydrochloride

B5705-10 10 mg
EUR 350.4

Q94 hydrochloride

B5705-50 50 mg
EUR 1264.8

GMQ hydrochloride

B5793-10 10 mg
EUR 212.4

GMQ hydrochloride

B5793-50 50 mg
EUR 711.6

AMT hydrochloride

B6480-10 10 mg
EUR 205.2

AMT hydrochloride

B6480-100 100 mg
EUR 1036.8

AMT hydrochloride

B6480-5 5 mg
EUR 141.6

AMT hydrochloride

B6480-50 50 mg
EUR 673.2

BEC (hydrochloride)

HY-19548A 25mg
EUR 570

EDC hydrochloride

GP0849-100G 100 g
EUR 141.6

EDC hydrochloride

GP0849-250G 250 g
EUR 237.6

EDC hydrochloride

GP0849-25G 25 g
EUR 84

EDC hydrochloride

GP0849-5G 5 g
EUR 55.2

SAG (hydrochloride)

HY-12848B 10mg
EUR 321.6

EDC hydrochloride

GP0849-100 100
EUR 87.1

EDC hydrochloride

GP0849-25 25
EUR 39.4

EDC hydrochloride

GP0849-250 250
EUR 166

EDC hydrochloride

GP0849-5 5
EUR 15.9

Trimethobenzamide hydrochloride

HY-12751A 200mg
EUR 241.2

AMTB hydrochloride

B2978-25 25 mg
EUR 812.4

AMTB hydrochloride

B2978-5 5 mg
EUR 247.2

MPEP hydrochloride

B1151-10 each
EUR 222

MPEP hydrochloride

B1151-50 each
EUR 705.6

S1RA hydrochloride

B1180-10 10 mg
EUR 1144.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-100 100 mg
EUR 4620
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-5 5 mg
EUR 819.6
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride

B1180-50 50 mg
EUR 3316.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

THZ1 Hydrochloride

B4736-10 10 mg
EUR 268.8
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-25 25 mg
EUR 477.6
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-5 5 mg
EUR 170.4
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride

B4736-5.1 10 mM (in 1mL DMSO)
EUR 205.2
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

EHNA hydrochloride

2265-25 each
EUR 339.6

EHNA hydrochloride

2265-5 each
EUR 138

TAME Hydrochloride

2050-100 each
EUR 151.2

TAME Hydrochloride

2050-1000 each
EUR 574.8

TAME Hydrochloride

2050-500 each
EUR 405.6

DMCM hydrochloride

B7268-10 10 mg
EUR 385.2

DMCM hydrochloride

B7268-100 100 mg
EUR 2210.4

DMCM hydrochloride

B7268-25 25 mg
EUR 776.4

DMCM hydrochloride

B7268-5 5 mg
EUR 277.2

DMCM hydrochloride

B7268-5.1 10 mM (in 1mL H2O)
EUR 297.6

DMCM hydrochloride

B7268-50 50 mg
EUR 1363.2

AMTB hydrochloride

B7559-10 10 mg
EUR 459.6

AMTB hydrochloride

B7559-50 50 mg
EUR 1746

MPEP Hydrochloride

A3633-10 10 mg
EUR 142.8
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPEP Hydrochloride

A3633-50 50 mg
EUR 379.2
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPTP hydrochloride

A3634-10 10 mg
EUR 162
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MPTP hydrochloride

A3634-50 50 mg
EUR 344.4
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MTEP hydrochloride

A3636-10 10 mg
EUR 205.2
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride

A3636-5 5 mg
EUR 153.6
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride

A3636-50 50 mg
EUR 686.4
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

PJ34 hydrochloride

A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

TCEP hydrochloride

B6055-10000 10 g
EUR 338.4
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride

B6055-2000 2 g
EUR 150
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride

B6055-50000 50 g
EUR 1243.2
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

HEAT hydrochloride

B6339-10 10 mg
EUR 321.6

HEAT hydrochloride

B6339-50 50 mg
EUR 1167.6

THIP hydrochloride

B6460-100 100 mg
EUR 358.8

THIP hydrochloride

B6460-25 25 mg
EUR 174

THIP hydrochloride

B6460-50 50 mg
EUR 243.6

EHNA hydrochloride

B6662-10 10 mg
EUR 145.2

EHNA hydrochloride

B6662-25 25 mg
EUR 262.8

N20C hydrochloride

B6980-10 10 mg
EUR 340.8

N20C hydrochloride

B6980-50 50 mg
EUR 1245.6

TMPH hydrochloride

B7053-10 10 mg
EUR 321.6

TMPH hydrochloride

B7053-50 50 mg
EUR 1167.6

DAPI (hydrochloride)

C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)

C3362-25 25 mg
EUR 240

DAPI (hydrochloride)

C3362-5 5 mg
EUR 111.6

AD57 (hydrochloride)

C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)

C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)

C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

MMAD hydrochloride

ADC-P-019 unit Ask for price

MMAF Hydrochloride

ADC-P-021 unit Ask for price

THZ1 hydrochloride

9544-25 each
EUR 1227.6

THZ1 hydrochloride

9544-5 each
EUR 366

EDAC, hydrochloride

EB0433 25g
EUR 123.68

TCEP (hydrochloride)

HY-W011500 10mM/1mL
EUR 135.6

MCLA hydrochloride

HY-W013275 5mg
EUR 381.6

DMCM (hydrochloride)

HY-100369A 100mg
EUR 1695.6

OABK (hydrochloride)

HY-100825 100mg
EUR 3531.6

EIPA (hydrochloride)

HY-101840A 10mM/1mL
EUR 151.2

(±)-ANAP hydrochloride

HY-101937C 5mg
EUR 817.2

EHNA (hydrochloride)

HY-103160A 5mg
EUR 170.4

MMAF (Hydrochloride)

HY-15579A 10mM/1mL
EUR 674.4

MPTP (hydrochloride)

HY-15608 50mg
EUR 308.4

K145 (hydrochloride)

HY-15779A 10mM/1mL
EUR 169.2

S1RA (hydrochloride)

HY-18099A 10mM/1mL
EUR 696

THZ1 (Hydrochloride)

HY-80013A 5mg
EUR 192

TAME Hydrochloride

GM4942-5G 5 g
EUR 90

ACHP (Hydrochloride)

HY-13060 100mg
EUR 1861.2

MTEP (hydrochloride)

HY-13206 10mg
EUR 200.4

TAME hydrochloride

HY-13255A 100mg
EUR 192

PJ34 (hydrochloride)

HY-13688 10mg
EUR 159.6

MPEP (Hydrochloride)

HY-14609 50mg
EUR 439.2

S107 hydrochloride

HY-15292A 50mg
EUR 804

TCEP hydrochloride

TB0974 1g
EUR 101.76

TAME Hydrochloride

GM4942-5 5
EUR 45.1

CPTH2 (hydrochloride)

B2815-1 each
EUR 144

CPTH2 (hydrochloride)

B2815-5 each
EUR 352.8

XL413 hydrochloride

B1015-10 10 mg
EUR 289.2
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-100 100 mg
EUR 1005.6
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-5 5 mg
EUR 205.2
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride

B1015-50 50 mg
EUR 714
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

SMANT hydrochloride

B5674-10 10 mg
EUR 350.4

SMANT hydrochloride

B5674-50 50 mg
EUR 1284

SBE13 hydrochloride

2847-10 each
EUR 222

SBE13 hydrochloride

2847-50 each
EUR 705.6

MS049 (hydrochloride)

C3776-10 10 mg
EUR 240
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-100 100 mg
EUR 1417.2
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-25 25 mg
EUR 458.4
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5 5 mg
EUR 166.8
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5.1 10 mM (in 1mL DMSO)
EUR 180
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-50 50 mg
EUR 783.6
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

VU590 (hydrochloride)

C4778-10 10 mg
EUR 234

VU590 (hydrochloride)

C4778-25 25 mg
EUR 466.8

VU590 (hydrochloride)

C4778-5 5 mg
EUR 166.8

MMPIP hydrochloride

B7234-1 1 mg
EUR 151.2

MMPIP hydrochloride

B7234-10 10 mg
EUR 308.4

MMPIP hydrochloride

B7234-50 50 mg
EUR 1024.8

ML241 hydrochloride

B6122-10 10 mg
EUR 247.2
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-100 100 mg
EUR 999.6
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-25 25 mg
EUR 373.2
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-50 50 mg
EUR 622.8
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

DIPPA hydrochloride

B6456-10 10 mg
EUR 369.6

DIPPA hydrochloride

B6456-50 50 mg
EUR 1363.2

NTNCB hydrochloride

B6957-10 10 mg
EUR 466.8

NTNCB hydrochloride

B6957-50 50 mg
EUR 1771.2

ACDPP hydrochloride

B6991-10 10 mg
EUR 350.4

ACDPP hydrochloride

B6991-50 50 mg
EUR 1284

CPTH2 (hydrochloride)

C3208-10 10 mg
EUR 231.6
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

CPTH2 (hydrochloride)

C3208-5 5 mg
EUR 192
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

MS023 (hydrochloride)

C3503-1 1 mg
EUR 134.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-10 10 mg
EUR 661.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-25 25 mg
EUR 1375.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-5 5 mg
EUR 398.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

RETRA hydrochloride

A4485-10 10 mg
EUR 369.6
Description: IC50: Inhibit tumor cells growth with an IC50of about 4 M.Being defective for the tumor-suppressor function, mutant p53, a major contributor to malignancy, exerts oncogenic activity also by blocking another tumor-suppressing protein - p73.

RETRA hydrochloride

A4485-50 50 mg
EUR 1363.2
Description: IC50: Inhibit tumor cells growth with an IC50of about 4 M.Being defective for the tumor-suppressor function, mutant p53, a major contributor to malignancy, exerts oncogenic activity also by blocking another tumor-suppressing protein - p73.

AEBSF hydrochloride

GE4678-1G 1 g
EUR 578.4

AEBSF hydrochloride

GE4678-250MG 250 mg
EUR 289.2

AEBSF hydrochloride

GE4678-50MG 50 mg
EUR 136.8

ZM223 (hydrochloride)

HY-101790A 50mg
EUR 3159.6

VU591 hydrochloride

HY-108585 5mg
EUR 308.4

BX471 (hydrochloride)

HY-12080A 10mg
EUR 267.6

SC144 (hydrochloride)

HY-15614A 25mg
EUR 294

CNDAC (hydrochloride)

HY-16445B 10mM/1mL
EUR 590.4

TH287 (hydrochloride)

HY-16965A 100mg
EUR 1383.6

ML241 (hydrochloride)

HY-19797A 100mg
EUR 1465.2

DiZPK Hydrochloride

HY-12801A 50mg
EUR 2126.4

TH588 (hydrochloride)

HY-12814A 50mg
EUR 456

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