objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.
method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.
result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.
Cyclodrine (hydrochloride) |
|||
HY-U00139 | MedChemExpress | 5mg | EUR 601 |
Drobuline (hydrochloride) |
|||
HY-U00149 | MedChemExpress | 5mg | EUR 877 |
Dopexamine hydrochloride |
|||
HY-U00205 | MedChemExpress | 1mg | EUR 463 |
AE0047 Hydrochloride |
|||
HY-U00284 | MedChemExpress | 20mg | EUR 3356 |
Bometolol Hydrochloride |
|||
HY-U00386 | MedChemExpress | 1mg | EUR 3218 |
GSK2850163 hydrochloride |
|||
HY-U00459B | MedChemExpress | 10mg | EUR 371 |
TCEP (hydrochloride) |
|||
HY-W011500 | MedChemExpress | 10mM/1mL | EUR 113 |
Tulobuterol (hydrochloride) |
|||
HY-W011733 | MedChemExpress | 500mg | EUR 199 |
MCLA hydrochloride |
|||
HY-W013275 | MedChemExpress | 5mg | EUR 318 |
Icotinib hydrochloride |
|||
I035-10MG | TOKU-E | 10 mg | EUR 347 |
Kasugamycin hydrochloride |
|||
K005-10G | TOKU-E | 10 g | EUR 276 |
Kasugamycin hydrochloride |
|||
K005-1G | TOKU-E | 1 g | EUR 86 |
Kasugamycin hydrochloride |
|||
K005-50G | TOKU-E | 50 g | EUR 868 |
Methacycline hydrochloride |
|||
M003-100MG | TOKU-E | 100 mg | EUR 139 |
Methacycline hydrochloride |
|||
M003-1G | TOKU-E | 1 g | EUR 187 |
Minocycline hydrochloride |
|||
M008-1G | TOKU-E | 1 g | EUR 347 |
Minocycline hydrochloride |
|||
M008-500MG | TOKU-E | 500 mg | EUR 200 |
Mitoxantrone hydrochloride |
|||
M010-50MG | TOKU-E | 50 mg | EUR 129 |
Lomefloxacin hydrochloride |
|||
L005-1G | TOKU-E | 1 g | EUR 74 |
Lomefloxacin hydrochloride |
|||
L005-5G | TOKU-E | 5 g | EUR 153 |
Daunorubicin hydrochloride |
|||
D001-10MG | TOKU-E | 10 mg | EUR 119 |
Daunorubicin hydrochloride |
|||
D001-50MG | TOKU-E | 50 mg | EUR 400 |
Difloxacin hydrochloride |
|||
D021-1G | TOKU-E | 1 g | EUR 111 |
Difloxacin hydrochloride |
|||
D021-5G | TOKU-E | 5 g | EUR 365 |
Demeclocycline hydrochloride |
|||
D032-1G | TOKU-E | 1 g | EUR 174 |
Demeclocycline hydrochloride |
|||
D032-250MG | TOKU-E | 250 mg | EUR 88 |
Demeclocycline hydrochloride |
|||
D032-5G | TOKU-E | 5 g | EUR 539 |
Doxycycline Hydrochloride |
|||
D065-25MG | TOKU-E | 25mg | EUR 342 |
Doxycycline Hydrochloride |
|||
D065-5MG | TOKU-E | 5mg | EUR 119 |
Dalbavancin Hydrochloride |
|||
D092-10MG | TOKU-E | 10mg | EUR 127 |
Dalbavancin Hydrochloride |
|||
D092-50MG | TOKU-E | 50mg | EUR 380 |
Dimethylamine hydrochloride |
|||
DB0410 | Bio Basic | 500g | EUR 96.98 |
Betaine hydrochloride |
|||
BB0133 | Bio Basic | 250g | EUR 75.52 |
Benzamidine hydrochloride |
|||
BD0076 | Bio Basic | 25g | EUR 81.32 |
Cefepime Hydrochloride |
|||
C009-100MG | TOKU-E | 100 mg | EUR 267 |
Ceftazidime Hydrochloride |
|||
C020-1G | TOKU-E | 1 g | EUR 622 |
Ciprofloxacin hydrochloride |
|||
C032-25G | TOKU-E | 25 g | EUR 166 |
Ciprofloxacin hydrochloride |
|||
C032-5G | TOKU-E | 5 g | EUR 62 |
Clindamycin Hydrochloride |
|||
C035-100MG | TOKU-E | 100 mg | EUR 203 |
Clindamycin Hydrochloride |
|||
C035-50MG | TOKU-E | 50 mg | EUR 127 |
Chlortetracycline Hydrochloride |
|||
C072-100G | TOKU-E | 100 g | EUR 314 |
Chlortetracycline Hydrochloride |
|||
C072-25G | TOKU-E | 25 g | EUR 131 |
Chlortetracycline Hydrochloride |
|||
C072-5G | TOKU-E | 5 g | EUR 65 |
Cefozopran Hydrochloride |
|||
C099-100MG | TOKU-E | 100 mg | EUR 250 |
Cysteamine hydrochloride |
|||
C212-25G | TOKU-E | 25 g | EUR 65 |
Cysteamine hydrochloride |
|||
C212-4x25G | TOKU-E | 4 x 25 g | EUR 129 |
Ceftiofur Hydrochloride |
|||
C228-1G | TOKU-E | 1 g | EUR 108 |
Ceftiofur Hydrochloride |
|||
C228-5G | TOKU-E | 5 g | EUR 323 |
Cefmenoxime Hydrochloride |
|||
C240-100MG | TOKU-E | 100mg | EUR 114 |
Cefmenoxime Hydrochloride |
|||
C240-500MG | TOKU-E | 500mg | EUR 279 |
Cinacalcet Hydrochloride |
|||
C242-100MG | TOKU-E | 100mg | EUR 428 |
Cinacalcet Hydrochloride |
|||
C242-10MG | TOKU-E | 10mg | EUR 79 |
Flavopiridol (Hydrochloride) |
|||
HY-10006 | MedChemExpress | 10mM/1mL | EUR 126 |
PRX933 hydrochloride |
|||
HY-100171 | MedChemExpress | 10mg | EUR 2258 |
Varenicline (Hydrochloride) |
|||
HY-10020 | MedChemExpress | 100mg | EUR 739 |
SKF89976A (hydrochloride) |
|||
HY-100228A | MedChemExpress | 10mg | EUR 173 |
ML133 (hydrochloride) |
|||
HY-100230A | MedChemExpress | 10mg | EUR 131 |
DMCM (hydrochloride) |
|||
HY-100369A | MedChemExpress | 100mg | EUR 1413 |
SHP099 (hydrochloride) |
|||
HY-100388A | MedChemExpress | 10mM/1mL | EUR 133 |
Nevanimibe hydrochloride |
|||
HY-100399A | MedChemExpress | 10mg | EUR 497 |
LY2365109 (hydrochloride) |
|||
HY-100416A | MedChemExpress | 100mg | EUR 1496 |
Lenampicillin (hydrochloride) |
|||
HY-100500 | MedChemExpress | 5mg | EUR 243 |
GSK484 (hydrochloride) |
|||
HY-100514 | MedChemExpress | 50mg | EUR 1187 |
VU0364770 (hydrochloride) |
|||
HY-100588A | MedChemExpress | 10mM/1mL | EUR 220 |
HJC0152 hydrochloride |
|||
HY-100602 | MedChemExpress | 100mg | EUR 946 |
Landiolol (hydrochloride) |
|||
HY-100607A | MedChemExpress | 10mM/1mL | EUR 119 |
Norverapamil (hydrochloride) |
|||
HY-100750 | MedChemExpress | 10mg | EUR 340 |
Pirmenol (hydrochloride) |
|||
HY-100795A | MedChemExpress | 100mg | EUR 2943 |
Guvacine hydrochloride |
|||
HY-100809 | MedChemExpress | 5mg | EUR 108 |
Isoguvacine (hydrochloride) |
|||
HY-100810 | MedChemExpress | 25mg | EUR 133 |
OABK (hydrochloride) |
|||
HY-100825 | MedChemExpress | 100mg | EUR 2943 |
Piperoxan (hydrochloride) |
|||
HY-100850 | MedChemExpress | 10mM/1mL | EUR 177 |
Olcegepant (hydrochloride) |
|||
HY-10095A | MedChemExpress | 50mg | EUR 1605 |
Naltrindole (hydrochloride) |
|||
HY-101177 | MedChemExpress | 50mg | EUR 698 |
Trilaciclib hydrochloride |
|||
HY-101467A | MedChemExpress | 10mM/1mL | EUR 969 |
Prodipine hydrochloride |
|||
HY-101605 | MedChemExpress | 20mg | EUR 877 |
Teludipine hydrochloride |
|||
HY-101621 | MedChemExpress | 1mg | EUR 601 |
Levophacetoperane (hydrochloride) |
|||
HY-101631 | MedChemExpress | 1mg | EUR 463 |
FK1052 hydrochloride |
|||
HY-101638 | MedChemExpress | 20mg | EUR 11869 |
Saterinone hydrochloride |
|||
HY-101644A | MedChemExpress | 20mg | EUR 4803 |
Pargolol hydrochloride |
|||
HY-101658 | MedChemExpress | 20mg | EUR 2530 |
Tiapamil hydrochloride |
|||
HY-101674 | MedChemExpress | 10mg | EUR 1924 |
Tecalcet (Hydrochloride) |
|||
HY-10167A | MedChemExpress | 5mg | EUR 142 |
ZM223 (hydrochloride) |
|||
HY-101790A | MedChemExpress | 50mg | EUR 2633 |
RG7800 hydrochloride |
|||
HY-101792A | MedChemExpress | 10mg | EUR 176 |
Dasatinib (hydrochloride) |
|||
HY-10181A | MedChemExpress | 500mg | EUR 185 |
EIPA (hydrochloride) |
|||
HY-101840A | MedChemExpress | 10mM/1mL | EUR 126 |
(±)-ANAP hydrochloride |
|||
HY-101937C | MedChemExpress | 5mg | EUR 681 |
Ruboxistaurin (hydrochloride) |
|||
HY-10195B | MedChemExpress | 10mg | EUR 337 |
Tandutinib (hydrochloride) |
|||
HY-10202A | MedChemExpress | 50mg | EUR 119 |
Amuvatinib hydrochloride |
|||
HY-10206A | MedChemExpress | 10mg | EUR 257 |
Retaspimycin (Hydrochloride) |
|||
HY-10210 | MedChemExpress | 100mg | EUR 1785 |
Gaboxadol (hydrochloride) |
|||
HY-10233 | MedChemExpress | 5mg | EUR 223 |
Vandetanib (hydrochloride) |
|||
HY-10260B | MedChemExpress | 25mg | EUR 133 |
EHNA (hydrochloride) |
|||
HY-103160A | MedChemExpress | 5mg | EUR 142 |
Amibegron hydrochloride |
|||
HY-103207 | MedChemExpress | 10mM/1mL | EUR 252 |