Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.

objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.


method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.


result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.
Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.


conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.

Stachydrine (hydrochloride)

C3648-250 250 mg
EUR 206
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-500 500 mg
EUR 328
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Barnidipine (hydrochloride)

C3727-100 100 mg
EUR 203
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Barnidipine (hydrochloride)

C3727-50 50 mg
EUR 155
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

MS049 (hydrochloride)

C3776-10 10 mg
EUR 200
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-100 100 mg
EUR 1181
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-25 25 mg
EUR 382
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5 5 mg
EUR 139
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-50 50 mg
EUR 653
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

Guanabenz (hydrochloride)

C3786-100 100 mg
EUR 231
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Guanabenz (hydrochloride)

C3786-50 50 mg
EUR 144
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Ulixertinib (hydrochloride)

C3921-10 10 mg
EUR 406
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-25 25 mg
EUR 661
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-5 5 mg
EUR 250
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Chlorcyclizine (hydrochloride)

C3989-100 100 mg
EUR 118
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-1000 1 g
EUR 595
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-250 250 mg
EUR 210
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-500 500 mg
EUR 357
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Lofexidine (hydrochloride)

C3990-1000 1 g
EUR 126
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)

C3990-5.1 10 mM (in 1mL H2O)
EUR 113
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)

C3990-500 500 mg
EUR 100
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Nortriptyline (hydrochloride)

C4077-100 100 mg
EUR 163
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)

C4077-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)

C4077-50 50 mg
EUR 116
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Imipramine (hydrochloride)

C4117-5.1 10 mM (in 1mL H2O)
EUR 113
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Imipramine (hydrochloride)

C4117-5000 5 g
EUR 108
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Clorgyline (hydrochloride)

C4137-100 100 mg
EUR 224
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)

C4137-25 25 mg
EUR 110
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)

C4137-50 50 mg
EUR 154
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Doxepin (hydrochloride)

C4153-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (hydrochloride)

C4153-5000 5 g
EUR 168
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Anhydrochlortetracycline (hydrochloride)

C4218-1 1 mg
EUR 132
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrochlortetracycline (hydrochloride)

C4218-5 5 mg
EUR 255
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrotetracycline (hydrochloride)

C4291-100 100 mg
EUR 241
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)

C4291-25 25 mg
EUR 123
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)

C4291-50 50 mg
EUR 171
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

(±)-Salsolinol (hydrochloride)

C4364-500 500 mg
EUR 308
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)

C4493-100 100 mg
EUR 113
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)

C4493-250 250 mg
EUR 200
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Celiprolol (hydrochloride)

C4521-10 10 mg
EUR 254
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-25 25 mg
EUR 500
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-5 5 mg
EUR 183
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)

C4635-1000 1 g
EUR 328

Aceclidine (hydrochloride)

C4635-500 500 mg
EUR 206

Trimidox (hydrochloride)

C4714-10 10 mg
EUR 184
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-25 25 mg
EUR 370
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-5 5 mg
EUR 121
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-50 50 mg
EUR 618
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Cycloguanil (hydrochloride)

C5763-10 10 mg
EUR 109
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)

C5763-25 25 mg
EUR 163
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)

C5763-50 50 mg
EUR 206
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

VU590 (hydrochloride)

C4778-10 10 mg
EUR 195

VU590 (hydrochloride)

C4778-25 25 mg
EUR 389

VU590 (hydrochloride)

C4778-5 5 mg
EUR 139

Bufuralol (hydrochloride)

C5043-1 1 mg
EUR 139
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)

C5043-10 10 mg
EUR 628
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)

C5043-5 5 mg
EUR 457
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

AN3365 (hydrochloride)

C5068-10 10 mg
EUR 328
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)

C5068-25 25 mg
EUR 659
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)

C5068-5 5 mg
EUR 206
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

Calindol (hydrochloride)

C5329-10 10 mg
EUR 440
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)

C5329-25 25 mg
EUR 902
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)

C5329-5 5 mg
EUR 270
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Kasugamycin (hydrochloride)

C5503-10000 10 g
EUR 350
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Kasugamycin (hydrochloride)

C5503-5000 5 g
EUR 251
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Ciprofloxacin (hydrochloride)

C5539-10000 10 g
EUR 116
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)

C5539-25000 25 g
EUR 154
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)

C5539-50000 50 g
EUR 224
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Fendiline (hydrochloride)

C5675-5000 5 g
EUR 122
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C.

Afuresertib hydrochloride

B1848-5
EUR 175

Chlorpromazine hydrochloride

B1992-100
EUR 120

Chlorpromazine hydrochloride

B1992-500
EUR 294

Triflupromazine hydrochloride

B1993-100
EUR 120

 ZLN024 hydrochloride

B2034-25
EUR 588

 ZLN024 hydrochloride

B2034-5
EUR 185

Topotecan hydrochloride

B2050-10
EUR 131

Givinostat hydrochloride

B2081-25
EUR 756

Givinostat hydrochloride

B2081-5
EUR 229

Moexipril hydrochloride

B2134-25
EUR 294

Imidapril hydrochloride

B2135-25
EUR 414

Imidapril hydrochloride

B2135-5
EUR 142

Benazepril hydrochloride

B2138-250
EUR 294

Benazepril hydrochloride

B2138-50
EUR 131

Dorzolamide hydrochloride

B2185-10
EUR 120

Dorzolamide hydrochloride

B2185-50
EUR 327

Eltoprazine hydrochloride

B2301-25
EUR 457

Eltoprazine hydrochloride

B2301-5
EUR 153

Papaverine hydrochloride

B2315-250
EUR 262

Papaverine hydrochloride

B2315-50
EUR 120

Sarecycline hydrochloride

B2383-25
EUR 588

Sarecycline hydrochloride

B2383-5
EUR 185

Sertraline (hydrochloride)

B2393-10
EUR 131

Sertraline (hydrochloride)

B2393-50
EUR 327

Migalastat hydrochloride

B2404-25
EUR 756

Migalastat hydrochloride

B2404-5
EUR 229

Butenafine hydrochloride

B2421-250
EUR 327

Butenafine hydrochloride

B2421-50
EUR 120

Naftifine hydrochloride

B2422-10
EUR 131

Naftifine hydrochloride

B2422-50
EUR 349

Rilpivirine hydrochloride

B2427-25
EUR 414

Rilpivirine hydrochloride

B2427-5
EUR 142

Tirabrutinib hydrochloride

B2556-25
EUR 457

Tirabrutinib hydrochloride

B2556-5
EUR 153

Robenidine hydrochloride

B2560-1G
EUR 131

Robenidine hydrochloride

B2560-5G
EUR 262

Sardomozide Hydrochloride

B2566-25
EUR 631

Sardomozide Hydrochloride

B2566-5
EUR 196

Riviciclib hydrochloride

B2567-1
EUR 142

Riviciclib hydrochloride

B2567-5
EUR 414

CPTH2 (hydrochloride)

B2815-1
EUR 120

CPTH2 (hydrochloride)

B2815-5
EUR 294

Resminostat (hydrochloride)

B2852-25
EUR 588

Resminostat (hydrochloride)

B2852-5
EUR 185

Almorexant hydrochloride

B3241-10 10 mg
EUR 440
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Almorexant hydrochloride

B3241-5 5 mg
EUR 270
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Memantine hydrochloride

B3308-200 200 mg
EUR 137
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine hydrochloride

B3308-S Evaluation Sample
EUR 81
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Cyproheptadine hydrochloride

B3309-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-50 50 mg
EUR 128
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Cyproheptadine hydrochloride

B3309-S Evaluation Sample
EUR 81
Description: Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1]. Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent.

Moxonidine hydrochloride

B3314-10 10 mg
EUR 195
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-100 100 mg
EUR 864
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Moxonidine hydrochloride

B3314-50 50 mg
EUR 502
Description: Moxonidine hydrochloride is a mixed agonist of ?2-adrenergic receptor (?2AR) and imidazoline-1 receptor(I1R) with Ki values of 4.2±3.2 nmol/L, 13.0±4.2 nmol/L.

Bupropion hydrochloride

B3326-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-50 50 mg
EUR 128
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Bupropion hydrochloride

B3326-S Evaluation Sample
EUR 81
Description: Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6?M and 3.4 ± 0.4 ?M, respectively [1].

Sotalol hydrochloride

B3341-100 100 mg
EUR 139
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-200 200 mg
EUR 187
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-5.1 10 mM (in 1mL DMSO)
EUR 119
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-50 50 mg
EUR 106
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Sotalol hydrochloride

B3341-S Evaluation Sample
EUR 81
Description: Sotalol hydrochloride is a potent and non-selective antagonist of ?-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1].

Miglustat hydrochloride

B3402-10 10 mg
EUR 312
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Miglustat hydrochloride

B3402-25 25 mg
EUR 641
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Miglustat hydrochloride

B3402-5 5 mg
EUR 195
Description: Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

Solifenacin hydrochloride

B3415-10 10 mg
EUR 321
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-100 100 mg
EUR 1407
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-5 5 mg
EUR 231
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-5.1 10 mM (in 1mL DMSO)
EUR 248
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Solifenacin hydrochloride

B3415-50 50 mg
EUR 864
Description: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic receptor antagonist.

Vigabatrin Hydrochloride

B3421-10 10 mg
EUR 142
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Vigabatrin Hydrochloride

B3421-25 25 mg
EUR 270
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Vigabatrin Hydrochloride

B3421-50 50 mg
EUR 440
Description: Vigabatrin Hcl(?-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.

Flavoxate hydrochloride

B3433-5 5 mg
EUR 131
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Flavoxate hydrochloride

B3433-5.1 10 mM (in 1mL DMSO)
EUR 166
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Flavoxate hydrochloride

B3433-50 50 mg
EUR 363
Description: Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

Tiagabine hydrochloride

B3443-10 10 mg
EUR 102

Tiagabine hydrochloride

B3443-5.1 10 mM (in 1mL DMSO)
EUR 108

Lercanidipine hydrochloride

B3482-10 10 mg
EUR 119

Lercanidipine hydrochloride

B3482-100 100 mg
EUR 453

Lercanidipine hydrochloride

B3482-200 200 mg
EUR 592

Lercanidipine hydrochloride

B3482-5.1 10 mM (in 1mL DMSO)
EUR 132

Lercanidipine hydrochloride

B3482-50 50 mg
EUR 313

Sarpogrelate hydrochloride

B3494-10 10 mg
EUR 139
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-100 100 mg
EUR 421
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Sarpogrelate hydrochloride

B3494-50 50 mg
EUR 322
Description: Ki: 8.39 nMSarpogrelate (MCI-9042) was shown to have the same affinity as ritanserin for 5-HT2A receptors, [1].The blockade of 5-HT2A receptors can inhibit thrombus formation suppresses platelet aggregation and inhibits vascular smooth muscle cell proliferation [2].

Ramosetron Hydrochloride

B3536-10 10 mg
EUR 126

Ramosetron Hydrochloride

B3536-100 100 mg
EUR 661

Ramosetron Hydrochloride

B3536-25 25 mg
EUR 222

Ramosetron Hydrochloride

B3536-50 50 mg
EUR 376

SMANT hydrochloride

B5674-10 10 mg
EUR 292

SMANT hydrochloride

B5674-50 50 mg
EUR 1070

Q94 hydrochloride

B5705-10 10 mg
EUR 292

Q94 hydrochloride

B5705-50 50 mg
EUR 1054

GMQ hydrochloride

B5793-10 10 mg
EUR 177

GMQ hydrochloride

B5793-50 50 mg
EUR 593

P005672 hydrochloride

B5855-10 10 mg
EUR 512

P005672 hydrochloride

B5855-25 25 mg
EUR 1001

P005672 hydrochloride

B5855-5 5 mg
EUR 295

TCEP hydrochloride

B6055-10000 10 g
EUR 282
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride

B6055-2000 2 g
EUR 125
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride

B6055-50000 50 g
EUR 1036
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

ML241 hydrochloride

B6122-10 10 mg
EUR 206
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-100 100 mg
EUR 833
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-25 25 mg
EUR 311
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

ML241 hydrochloride

B6122-50 50 mg
EUR 519
Description: IC50: 100 nMML241 is identified as a p97 ATPase inhibitor.

Trihexyphenidyl hydrochloride

B6130-1000 1 g
EUR 134

Trihexyphenidyl hydrochloride

B6130-5.1 10 mM (in 1mL DMSO)
EUR 150

Itopride hydrochloride

B6138-100 100 mg
EUR 119
Description: IC50: 2.04 ?MItopride is an acetylcholinesterase (AchE) inhibitor.Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

Itopride hydrochloride

B6138-1000 1 g
EUR 241
Description: IC50: 2.04 ?MItopride is an acetylcholinesterase (AchE) inhibitor.Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

Itopride hydrochloride

B6138-5.1 10 mM (in 1mL DMSO)
EUR 132
Description: IC50: 2.04 ?MItopride is an acetylcholinesterase (AchE) inhibitor.Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

Itopride hydrochloride

B6138-500 500 mg
EUR 174
Description: IC50: 2.04 ?MItopride is an acetylcholinesterase (AchE) inhibitor.Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

Itopride hydrochloride

B6138-5000 5 g
EUR 660
Description: IC50: 2.04 ?MItopride is an acetylcholinesterase (AchE) inhibitor.Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

Guvacine hydrochloride

B6229-100 100 mg
EUR 276

Guvacine hydrochloride

B6229-25 25 mg
EUR 112

Guvacine hydrochloride

B6229-250 250 mg
EUR 551

Guvacine hydrochloride

B6229-50 50 mg
EUR 164

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