Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.

objective
To compare the efficacy of platinum and non-platinum-based regimens as first-line treatment for triple-negative breast cancer is advanced (TNBC) and analyze the relationship between their success and status of the BRCA genes.


method
Retrospectively analyzed clinical data from 220 patients diagnosed with advanced pathological TNBC and treated in the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the effectiveness of chemotherapy. A total of 114 patients had BRCA1 / 2 genes were tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between efficacy and BRCA1 / 2 gene status.


result
non-platinum-based chemotherapy (NPCT) was given to 129 and platinum-based chemotherapy (PBCT) to 91 study patients. The level of clinical benefit (CBR) and median progression-free survival (PFS) were not statistically different between groups NPCT and PBCT. Overall average life (OS) was 30.0 and 22.5 months for PBCT and NPCT groups, respectively [P = 0.090, hazard ratio (HR) = 0.703]. BRCA status assessed 114 patients, 14 of whom have a detrimental germline BRCA1 / 2 (gBRCA) mutation (seven in each group). In PBCT group, CBR was 85.7% and 35.1% for patients with and without mutations that destroy gBRCA, respectively (P = 0.039). Median PFS was 14.9 and 5.3 months and the median OS was 26.5 and 15.5 months for patients with and without mutations that destroy gBRCA, respectively (P = 0.001, P = 0.161, respectively). Patients in group PBCT have significantly greater levels of grade 3-4 anemia (5.5% vs. 0%) and thrombocytopenia (8.8% vs 0%), while the palmar-plantar erythrodysesthesia (12.4% vs 0% ) and peripheral neuropathy (8.6% vs. 1.1%) occurred more frequently in the group NPCT.

Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.
Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing.


conclusion
platinum-based regimen was more effective in patients with mutations gBRCA damage, but there was no difference in patients without BRCA gene mutation, so that the non-platinum is an option in patients without BRCA gene mutation consider the toxicity and side effects. And we suggest that patients with advanced TNBC must have a BRCA gene test.

Ciprofloxacin hydrochloride

C032-5G 5 g
EUR 74.4

Clindamycin Hydrochloride

C035-100MG 100 mg
EUR 243.6

Clindamycin Hydrochloride

C035-50MG 50 mg
EUR 152.4

Chlortetracycline Hydrochloride

C072-100G 100 g
EUR 376.8

Chlortetracycline Hydrochloride

C072-25G 25 g
EUR 157.2

Chlortetracycline Hydrochloride

C072-5G 5 g
EUR 78

Cefozopran Hydrochloride

C099-100MG 100 mg
EUR 300

Cysteamine hydrochloride

C212-25G 25 g
EUR 78

Cysteamine hydrochloride

C212-4x25G 4 x 25 g
EUR 154.8

Ceftiofur Hydrochloride

C228-1G 1 g
EUR 129.6

Ceftiofur Hydrochloride

C228-5G 5 g
EUR 387.6

Cefmenoxime Hydrochloride

C240-100MG 100mg
EUR 136.8

Cefmenoxime Hydrochloride

C240-500MG 500mg
EUR 334.8

Cinacalcet Hydrochloride

C242-100MG 100mg
EUR 513.6

Cinacalcet Hydrochloride

C242-10MG 10mg
EUR 94.8

Enrofloxacin hydrochloride

E007-100MG 100 mg
EUR 147.6

Enrofloxacin hydrochloride

E007-1G 1 g
EUR 776.4

Enrofloxacin hydrochloride

E007-500MG 500 mg
EUR 475.2

Erlotinib hydrochloride

E017-100MG 100 mg
EUR 136.8

Erlotinib hydrochloride

E017-1G 1 g
EUR 373.2

Pazopanib Hydrochloride

A8347-100 100 mg
EUR 268.8
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride

A8347-25 25 mg
EUR 129.6
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride

A8347-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

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A8347-500 500 mg
EUR 727.2
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A8347-S Evaluation Sample
EUR 97.2
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A8621-10 10 mg
EUR 157.2
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

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A8621-100 100 mg
EUR 532.8
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A8621-25 25 mg
EUR 226.8
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A8621-5 5 mg
EUR 129.6
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A8640-10 10 mg
EUR 129.6
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A8640-100 100 mg
EUR 528
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A8640-1000 1 g
EUR 3259.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A8640-25 25 mg
EUR 199.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A8640-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A3750-10 10 mg
EUR 150
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Regorafenib hydrochloride

A3750-100 100 mg
EUR 282
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Regorafenib hydrochloride

A3750-200 200 mg
EUR 582
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride

A3750-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride

A3750-50 50 mg
EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

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A3755-10 10 mg
EUR 428.4
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A3755-100 100 mg
EUR 1905.6
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

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A3755-5.1 10 mM (in 1mL DMSO)
EUR 464.4
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

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A3755-50 50 mg
EUR 1209.6
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A3766-10 10 mg
EUR 186
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

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A3766-100 100 mg
EUR 710.4
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Rimonabant hydrochloride

A3766-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

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A3766-50 50 mg
EUR 494.4
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Rotigotine hydrochloride

A3777-100 100 mg
EUR 480
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

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A3777-200 200 mg
EUR 812.4
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride

A3777-5.1 10 mM (in 1mL DMSO)
EUR 417.6
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride

A3777-50 50 mg
EUR 360
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Rotigotine hydrochloride

A3777-500 500 mg
EUR 1663.2
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Tipiracil hydrochloride

A3875-10 10 mg
EUR 553.2
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-25 25 mg
EUR 774
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-5 5 mg
EUR 382.8
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

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A3875-5.1 10 mM (in 1mL DMSO)
EUR 351.6
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-50 50 mg
EUR 1230
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Vandetanib hydrochloride

A3906-100 100 mg
EUR 517.2
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland.

Vandetanib hydrochloride

A3906-25 25 mg
EUR 201.6
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Vernakalant Hydrochloride

A3915-10 10 mg
EUR 847.2
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride

A3915-100 100 mg
EUR 3316.8
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride

A3915-50 50 mg
EUR 2090.4
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Vilazodone Hydrochloride

A3919-10 10 mg
EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

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A3919-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

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A3919-50 50 mg
EUR 157.2
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Voreloxin Hydrochloride

A3925-10 10 mg
EUR 895.2
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride

A3925-5 5 mg
EUR 656.4
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride

A3925-5.1 10 mM (in 1mL DMSO)
EUR 717.6
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

PJ34 hydrochloride

A4159-10 10 mg
EUR 142.8
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PJ34 hydrochloride

A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

Dimethylamine hydrochloride

DB0410 500g
EUR 116.38

Daunorubicin hydrochloride

D001-10MG 10 mg
EUR 142.8

Daunorubicin hydrochloride

D001-50MG 50 mg
EUR 480

Difloxacin hydrochloride

D021-1G 1 g
EUR 133.2

Difloxacin hydrochloride

D021-5G 5 g
EUR 438

Demeclocycline hydrochloride

D032-1G 1 g
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Demeclocycline hydrochloride

D032-250MG 250 mg
EUR 105.6

Demeclocycline hydrochloride

D032-5G 5 g
EUR 646.8

Doxycycline Hydrochloride

D065-25MG 25mg
EUR 410.4

Doxycycline Hydrochloride

D065-5MG 5mg
EUR 142.8

Dalbavancin Hydrochloride

D092-10MG 10mg
EUR 152.4

Dalbavancin Hydrochloride

D092-50MG 50mg
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Cefepime Hydrochloride

C009-100MG 100 mg
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C020-1G 1 g
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Niguldipine (hydrochloride)

C3067-10 10 mg
EUR 164.4
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Niguldipine (hydrochloride)

C3067-25 25 mg
EUR 308.4
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist.

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C3080-1 1 mg
EUR 141.6
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AD57 (hydrochloride)

C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

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C3080-5 5 mg
EUR 428.4
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Pargyline (hydrochloride)

C3106-1000 1 g
EUR 139.2
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Pargyline (hydrochloride)

C3106-5000 5 g
EUR 410.4
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Clenbuterol (hydrochloride)

C3119-100 100 mg
EUR 258
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-25 25 mg
EUR 130.8
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-50 50 mg
EUR 189.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

CBL0137 (hydrochloride)

C3192-10 10 mg
EUR 529.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-25 25 mg
EUR 1071.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-5 5 mg
EUR 331.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-5.1 10 mM (in 1mL DMSO)
EUR 282
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-50 50 mg
EUR 1851.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CPTH2 (hydrochloride)

C3208-10 10 mg
EUR 231.6
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

CPTH2 (hydrochloride)

C3208-5 5 mg
EUR 192
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

Clinafloxacin (hydrochloride)

C3345-100 100 mg
EUR 184.8
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-1000 1 g
EUR 686.4
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-250 250 mg
EUR 309.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-500 500 mg
EUR 459.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Isoxsuprine (hydrochloride)

C3347-10000 10 g
EUR 145.2
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

Isoxsuprine (hydrochloride)

C3347-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

DAPI (hydrochloride)

C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)

C3362-25 25 mg
EUR 240

DAPI (hydrochloride)

C3362-5 5 mg
EUR 111.6

Kanosamine (hydrochloride)

C3461-10 10 mg
EUR 528
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)

C3461-25 25 mg
EUR 1089.6
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)

C3461-5 5 mg
EUR 324
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Zoniporide (hydrochloride)

C3480-10 10 mg
EUR 278.4
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)

C3480-5 5 mg
EUR 181.2
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)

C3480-50 50 mg
EUR 1004.4
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

MS023 (hydrochloride)

C3503-1 1 mg
EUR 134.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-10 10 mg
EUR 661.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-25 25 mg
EUR 1375.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)

C3503-5 5 mg
EUR 398.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

Chlorprothixene (hydrochloride)

C3509-1000 1 g
EUR 103.2
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-10000 10 g
EUR 397.2
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-25000 25 g
EUR 796.8
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)

C3509-5000 5 g
EUR 249.6
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Cycloguanil (hydrochloride)

C5763-10 10 mg
EUR 130.8
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)

C5763-25 25 mg
EUR 195.6
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)

C5763-50 50 mg
EUR 247.2
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Bufuralol (hydrochloride)

C5043-1 1 mg
EUR 166.8
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)

C5043-10 10 mg
EUR 753.6
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)

C5043-5 5 mg
EUR 548.4
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

AN3365 (hydrochloride)

C5068-10 10 mg
EUR 393.6
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)

C5068-25 25 mg
EUR 790.8
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)

C5068-5 5 mg
EUR 247.2
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

Calindol (hydrochloride)

C5329-10 10 mg
EUR 528
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)

C5329-25 25 mg
EUR 1082.4
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)

C5329-5 5 mg
EUR 324
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Kasugamycin (hydrochloride)

C5503-10000 10 g
EUR 420
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Kasugamycin (hydrochloride)

C5503-5000 5 g
EUR 301.2
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Ciprofloxacin (hydrochloride)

C5539-10000 10 g
EUR 139.2
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)

C5539-25000 25 g
EUR 184.8
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)

C5539-50000 50 g
EUR 268.8
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Fendiline (hydrochloride)

C5675-5000 5 g
EUR 146.4
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C.

Daunorubicin Hydrochloride

ADC-P-011 unit Ask for price

Doxorubicin hydrochloride

ADC-P-014 unit Ask for price

MMAD hydrochloride

ADC-P-019 unit Ask for price

MMAF Hydrochloride

ADC-P-021 unit Ask for price

Taltobulin hydrochloride

ADC-P-027 unit Ask for price

Moxifloxacin hydrochloride

E1KS1465 50mg
EUR 296.4

(±)-Salsolinol (hydrochloride)

C4364-500 500 mg
EUR 369.6
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)

C4493-100 100 mg
EUR 135.6
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)

C4493-250 250 mg
EUR 240
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Celiprolol (hydrochloride)

C4521-10 10 mg
EUR 304.8
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-25 25 mg
EUR 600
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)

C4521-5 5 mg
EUR 219.6
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)

C4635-1000 1 g
EUR 393.6

Aceclidine (hydrochloride)

C4635-500 500 mg
EUR 247.2

Trimidox (hydrochloride)

C4714-10 10 mg
EUR 220.8
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-25 25 mg
EUR 444
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-5 5 mg
EUR 145.2
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)

C4714-50 50 mg
EUR 741.6
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

VU590 (hydrochloride)

C4778-10 10 mg
EUR 234

VU590 (hydrochloride)

C4778-25 25 mg
EUR 466.8

VU590 (hydrochloride)

C4778-5 5 mg
EUR 166.8

Stachydrine (hydrochloride)

C3648-100 100 mg
EUR 142.8
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-1000 1 g
EUR 560.4
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-250 250 mg
EUR 247.2
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)

C3648-500 500 mg
EUR 393.6
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Barnidipine (hydrochloride)

C3727-100 100 mg
EUR 243.6
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Barnidipine (hydrochloride)

C3727-50 50 mg
EUR 186
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

MS049 (hydrochloride)

C3776-10 10 mg
EUR 240
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-100 100 mg
EUR 1417.2
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-25 25 mg
EUR 458.4
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5 5 mg
EUR 166.8
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-5.1 10 mM (in 1mL DMSO)
EUR 180
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)

C3776-50 50 mg
EUR 783.6
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

Guanabenz (hydrochloride)

C3786-100 100 mg
EUR 277.2
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Guanabenz (hydrochloride)

C3786-50 50 mg
EUR 172.8
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Ulixertinib (hydrochloride)

C3921-10 10 mg
EUR 487.2
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-25 25 mg
EUR 793.2
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)

C3921-5 5 mg
EUR 300
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Chlorcyclizine (hydrochloride)

C3989-100 100 mg
EUR 141.6
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-1000 1 g
EUR 714
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-250 250 mg
EUR 252
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)

C3989-500 500 mg
EUR 428.4
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

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